A COMPARATIVE STUDY BETWEEN PRESERVATIVE ARTIFICIAL TEARS AND PRESERVATIVE-FREE ARTIFICIAL TEARS ON TEAR FILM STABILITY AMONG DRY EYE PATIENTS
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Abstract
This comparative study investigated the effects of preservative and preservative-free artificial tears on tear stability among dry eye patients. The participants completed the OSDI questionnaire to determine their subjective observations. A randomized controlled trial was used to group the participants. Tear film stability was assessed using fluorescein invasive tear break-up time (FTBUT), Schirmer’s test was carried out to determine the tear flow rate, the results were compared between the two groups. The results showed that the mean values for TBUT for Hypromellose were 6.25 ± 0.33 before and 6.75 ± 0.31seconds after, for Refresh was 6.40 ± 0.40 before and 7.55 ± 0.42 seconds after. Also, the mean values for TFR for Hypromellose were 8.36 ± 0.50 before and 8.61 ± 0.50 seconds after, for refresh was 9.69 ± 0.54 before and 10.05 ± 0.55 after seconds. The results obtained were analyzed using the SSPS 22.0. T-test and one- way ANOVA were used to compare the mean FTBUT and TFR values between both groups, the p values were 0.64 and 0.68 respectively. There was no statistically significant difference in the tear film stability and tear flow rate between both groups after four weeks (p > 0.05). In conclusion, the results of this study showed that there was no notable difference between preservative artificial tears and preservative-free artificial tears on tear film stability and tear flow rate. It is recommended that clinicians can confidently recommend both preservative and preservative-free artificial tears as effective management options for dry eye. KEYWORDS: Dry eye syndrome, Artificial tears, Preservative, TBUT
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