HEPATITIS B

Hepatitis B virus (HBV) and Human Immunodeficiency Virus (HIV) are major global health concerns, particularly in sub-Saharan Africa. Nigeria accounts for a substantial burden, with millions affected by both viruses. HBV and HIV share common transmission routes and pose serious health risks, especially among immunocompromised individuals such as oncology patients. The aim of this study is to determine the seroprevalence of HBV and HIV among oncology patients attending secondary and tertiary health facilities in Benin City, Edo State, Nigeria. A cross-sectional study was conducted among oncology patients at the University Of Benin Teaching Hospital. A total of 150 consenting patients were recruited for the study. Data were collected using structured questionnaires. Venous blood samples (3ml) were collected, and analyzed for Hepatitis B surface antigen (HBsAg) and HIV antibodies using rapid diagnostic test kits following standard procedures and manufacturer’s instructions. Females constituted the majority of the study population. The results in this study showed total seroprevalence of HIV was 4% (3 males and 3 females) , while HBV was 2% ( 1 male and 2 females) . Infections were only recorded among patients with carcinoma-type cancers with a prevalence of 4.8% and 2.4% for HIV and HBV respectively. Age-specific analysis showed that HIV infection was most prevalent in age groups 51-60 (7.4%) and 41–50 (6.7%). HBV prevalence was highest among patients ages 51–60 (7.4%). Age and sex showed not statistical significant in influencing infection. Awareness level revealed that although all participants had heard of HIV, only a small portion was aware of HBV. In conclusion, these findings observed a measurable prevalence of HIV and HBV among oncology patients in Benin City. Increased awareness of viral infections, particularly among high-risk groups should be implemented to improve early detection, prevent reactivation (HBV) during immunosuppressive therapy, and reduce complications related to coinfection.

Background: Hepatitis B Virus (HBV) infection is a potential occupational biological hazard to medical and nursing students who are frequently exposed to blood and bodily fluids during clinical rotations, and the Hepatitis B vaccine is one of the most effective and safest prevention measures. Objectives: This study aimed to assess and compare the knowledge, attitude, and uptake of the Hepatitis B vaccination, including its determinants, among medical and nursing students at the University of Benin, Edo State, Nigeria. Methodology: A comparative cross-sectional study was conducted from December 2024 to March 2026, among 646 respondents, comprising 324 medical students and 322 nursing students. A multistage sampling technique was used to select students across preclinical and clinical levels. Data was collected using a pretested, structured, self-administered questionnaire and analysed using SPSS version 25. Bivariate (Chi-square) and multivariate (Binary Logistic Regression) analyses were utilised, with statistical significance set at p < 0.05. Results: The mean age of the respondents was 22.47 ± 2.72 years. Overall, 83.0% of respondents demonstrated good knowledge of Hepatitis B and its vaccination, while 17.0% had poor knowledge. Most respondents (91.0%) exhibited a positive attitude, which was strongly predicted by good knowledge (OR = 4.078; p < 0.001). However, actual vaccination uptake was critically low, with 73.8% of students remaining completely unvaccinated and only 10.7% having completed the three-dose series. Logistic regression showed that clinical exposure significantly predicted good knowledge (p < 0.001), while course of study predicted vaccination uptake, with medical students significantly more likely to be vaccinated than nursing students 15 (OR = 2.035; p = 0.022). Lack of awareness of vaccination centres (42.1%), vaccine cost (28.9%), and lack of time (26.4%) were reported as the major barriers to vaccination. Conclusion: Despite possessing high theoretical knowledge and a positive attitude towards the HBV vaccine, the actual vaccination practice among medical and nursing students is critically inadequate. Systemic barriers, specifically cost and logistical challenges, are the primary barriers preventing positive attitudes from translating into practice. Strengthening targeted awareness campaigns, subsidising vaccine costs, and integrating proactive vaccination policies into the curriculum will enhance uptake and optimise occupational safety during clinical training.

BACKGROUND: Hepatitis B remains a major global public health problem, particularly in low- and middle-income countries such as Nigeria, where it contributes significantly to chronic liver disease, cirrhosis, and hepatocellular carcinoma. Despite the availability of an effective vaccine, poor knowledge of the infection and its vaccine, as well as low vaccine uptake, continue to sustain transmission. AIM: This study assessed knowledge of the Hepatitis B vaccine, vaccination uptake, associated factors, and barriers to uptake of the vaccine among young adults in Benin City, Edo State. METHODS: A descriptive cross-sectional study was conducted among 543 respondents selected using a multistage sampling technique. Data was collected using a pretested structured interviewer and self-administered questionnaire covering socio-demographic characteristics, knowledge of Hepatitis B virus infection, knowledge of the Hepatitis B vaccine, vaccination status, and factors associated with these outcomes. Data was analyzed using IBM SPSS Statistics version 27.0. Univariate analysis summarized means, frequencies, and percentages. Bivariate analysis using chi-square tests determined associations between socio-demographic factors and respondents’ knowledge of Hepatitis B infection, knowledge of the vaccine, and vaccination uptake. Binary logistic regression identified predictors of good vaccine knowledge and full vaccination status. Statistical significance was set at p < 0.05, and results were presented in prose and tables. RESULTS: A total of 543 individuals took part in the study. The mean age of participants was 21.0 ± 2.8 years and 302 (55.6%) were females. Overall, 99 (24.6%) respondents had good knowledge of Hepatitis B virus infection, while 303 (75.4%) had poor knowledge. Regarding knowledge of the Hepatitis B vaccine, 50 (16.9%) had good knowledge, while 246 xv (83.1%) had poor knowledge. At the bivariate level, respondents age (χ²=17.131, p= <0.001), sex (χ²=5.122, p= 0.024), monthly income (χ²=14.319, p= 0.001), and individuals with good knowledge of Hepatitis B infection (χ²=91.056, p= <0.001) were significantly associated with
knowledge of the vaccine. Older respondents, females, individuals with higher monthly income, and those with good knowledge of Hepatitis B infection were more likely to have good knowledge compared to their counterparts. Ethnic group, marital status, religion, employment status and occupation were not statistically significant. Multivariate analysis showed that respondents earning ≥₦70,000 were 2.467 times more likely to have good knowledge of the vaccine (95% CI: 0.909–6.698), while respondents with good knowledge of Hepatitis B infection were 45.414 times more likely to have good knowledge of the vaccine (95% CI: 12.092–170.561), this was statistically significant (p < 0.001). Regarding vaccine uptake, 33 (6.1%) respondents were fully vaccinated, 66 (12.2%) were partially vaccinated, and 444 (81.8%) were not vaccinated. Bivariate analysis showed that age (χ² = 36.067, p < 0.001), sex (χ² = 10.591, p = 0.005), knowledge of Hepatitis B infection (χ² = 105.384, p < 0.001), and knowledge of the Hepatitis B vaccine (χ² = 93.812, p < 0.001) were significantly associated with vaccination status. Respondents aged ≥25 years had the
highest proportion of full vaccination 12 (16.7%), while those aged <20 years had the highest proportion of non-vaccination 190 (92.2%). Females had a higher proportion of partial vaccination 49 (16.2%), while males had a higher proportion of non-vaccination 206 (86.7%). Among respondents with good knowledge of Hepatitis B infection, 27 (27.3%) were fully vaccinated compared to 5 (1.7%) among those with poor knowledge. Similarly, 21 (42.0%) respondents with good vaccine knowledge were fully vaccinated compared to 9 (3.7%) among those with poor knowledge. Multivariate analysis showed that respondents with good knowledge of Hepatitis B infection were 9.011 times more likely to be fully vaccinated (95% xvi CI: 1.962–41.393, p = 0.005), while those with good knowledge of the Hepatitis B vaccine were 5.618 times more likely to be fully vaccinated (95% CI: 1.813–17.410, p = 0.003).
CONCLUSION: Knowledge of Hepatitis B infection and its vaccine was generally poor among respondents, and vaccination uptake was suboptimal. However, better knowledge of the infection and vaccine significantly improved the likelihood of full vaccination. Strengthening health education and awareness campaigns through healthcare workers, schools, and media platforms is essential to improve knowledge and increase vaccine uptake among the population.