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BACKGROUND: Hepatitis B remains a major global public health problem, particularly in low- and middle-income countries such as Nigeria, where it contributes significantly to chronic liver disease, cirrhosis, and hepatocellular carcinoma. Despite the availability of an effective vaccine, poor knowledge of the infection and its vaccine, as well as low vaccine uptake, continue to sustain transmission. AIM: This study assessed knowledge of the Hepatitis B vaccine, vaccination uptake, associated factors, and barriers to uptake of the vaccine among young adults in Benin City, Edo State. METHODS: A descriptive cross-sectional study was conducted among 543 respondents selected using a multistage sampling technique. Data was collected using a pretested structured interviewer and self-administered questionnaire covering socio-demographic characteristics, knowledge of Hepatitis B virus infection, knowledge of the Hepatitis B vaccine, vaccination status, and factors associated with these outcomes. Data was analyzed using IBM SPSS Statistics version 27.0. Univariate analysis summarized means, frequencies, and percentages. Bivariate analysis using chi-square tests determined associations between socio-demographic factors and respondents’ knowledge of Hepatitis B infection, knowledge of the vaccine, and vaccination uptake. Binary logistic regression identified predictors of good vaccine knowledge and full vaccination status. Statistical significance was set at p < 0.05, and results were presented in prose and tables. RESULTS: A total of 543 individuals took part in the study. The mean age of participants was 21.0 ± 2.8 years and 302 (55.6%) were females. Overall, 99 (24.6%) respondents had good knowledge of Hepatitis B virus infection, while 303 (75.4%) had poor knowledge. Regarding knowledge of the Hepatitis B vaccine, 50 (16.9%) had good knowledge, while 246 xv (83.1%) had poor knowledge. At the bivariate level, respondents age (χ²=17.131, p= <0.001), sex (χ²=5.122, p= 0.024), monthly income (χ²=14.319, p= 0.001), and individuals with good knowledge of Hepatitis B infection (χ²=91.056, p= <0.001) were significantly associated with
knowledge of the vaccine. Older respondents, females, individuals with higher monthly income, and those with good knowledge of Hepatitis B infection were more likely to have good knowledge compared to their counterparts. Ethnic group, marital status, religion, employment status and occupation were not statistically significant. Multivariate analysis showed that respondents earning ≥₦70,000 were 2.467 times more likely to have good knowledge of the vaccine (95% CI: 0.909–6.698), while respondents with good knowledge of Hepatitis B infection were 45.414 times more likely to have good knowledge of the vaccine (95% CI: 12.092–170.561), this was statistically significant (p < 0.001). Regarding vaccine uptake, 33 (6.1%) respondents were fully vaccinated, 66 (12.2%) were partially vaccinated, and 444 (81.8%) were not vaccinated. Bivariate analysis showed that age (χ² = 36.067, p < 0.001), sex (χ² = 10.591, p = 0.005), knowledge of Hepatitis B infection (χ² = 105.384, p < 0.001), and knowledge of the Hepatitis B vaccine (χ² = 93.812, p < 0.001) were significantly associated with vaccination status. Respondents aged ≥25 years had the
highest proportion of full vaccination 12 (16.7%), while those aged <20 years had the highest proportion of non-vaccination 190 (92.2%). Females had a higher proportion of partial vaccination 49 (16.2%), while males had a higher proportion of non-vaccination 206 (86.7%). Among respondents with good knowledge of Hepatitis B infection, 27 (27.3%) were fully vaccinated compared to 5 (1.7%) among those with poor knowledge. Similarly, 21 (42.0%) respondents with good vaccine knowledge were fully vaccinated compared to 9 (3.7%) among those with poor knowledge. Multivariate analysis showed that respondents with good knowledge of Hepatitis B infection were 9.011 times more likely to be fully vaccinated (95% xvi CI: 1.962–41.393, p = 0.005), while those with good knowledge of the Hepatitis B vaccine were 5.618 times more likely to be fully vaccinated (95% CI: 1.813–17.410, p = 0.003).
CONCLUSION: Knowledge of Hepatitis B infection and its vaccine was generally poor among respondents, and vaccination uptake was suboptimal. However, better knowledge of the infection and vaccine significantly improved the likelihood of full vaccination. Strengthening health education and awareness campaigns through healthcare workers, schools, and media platforms is essential to improve knowledge and increase vaccine uptake among the population.
knowledge of the vaccine. Older respondents, females, individuals with higher monthly income, and those with good knowledge of Hepatitis B infection were more likely to have good knowledge compared to their counterparts. Ethnic group, marital status, religion, employment status and occupation were not statistically significant. Multivariate analysis showed that respondents earning ≥₦70,000 were 2.467 times more likely to have good knowledge of the vaccine (95% CI: 0.909–6.698), while respondents with good knowledge of Hepatitis B infection were 45.414 times more likely to have good knowledge of the vaccine (95% CI: 12.092–170.561), this was statistically significant (p < 0.001). Regarding vaccine uptake, 33 (6.1%) respondents were fully vaccinated, 66 (12.2%) were partially vaccinated, and 444 (81.8%) were not vaccinated. Bivariate analysis showed that age (χ² = 36.067, p < 0.001), sex (χ² = 10.591, p = 0.005), knowledge of Hepatitis B infection (χ² = 105.384, p < 0.001), and knowledge of the Hepatitis B vaccine (χ² = 93.812, p < 0.001) were significantly associated with vaccination status. Respondents aged ≥25 years had the
highest proportion of full vaccination 12 (16.7%), while those aged <20 years had the highest proportion of non-vaccination 190 (92.2%). Females had a higher proportion of partial vaccination 49 (16.2%), while males had a higher proportion of non-vaccination 206 (86.7%). Among respondents with good knowledge of Hepatitis B infection, 27 (27.3%) were fully vaccinated compared to 5 (1.7%) among those with poor knowledge. Similarly, 21 (42.0%) respondents with good vaccine knowledge were fully vaccinated compared to 9 (3.7%) among those with poor knowledge. Multivariate analysis showed that respondents with good knowledge of Hepatitis B infection were 9.011 times more likely to be fully vaccinated (95% xvi CI: 1.962–41.393, p = 0.005), while those with good knowledge of the Hepatitis B vaccine were 5.618 times more likely to be fully vaccinated (95% CI: 1.813–17.410, p = 0.003).
CONCLUSION: Knowledge of Hepatitis B infection and its vaccine was generally poor among respondents, and vaccination uptake was suboptimal. However, better knowledge of the infection and vaccine significantly improved the likelihood of full vaccination. Strengthening health education and awareness campaigns through healthcare workers, schools, and media platforms is essential to improve knowledge and increase vaccine uptake among the population.
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