FADOGIA CIENKOWSKII SCHWEINF

Background: Fadogia cienkowskii is used as a herb for treating inflammation Aim: To evaluate the acute toxicity profile of Fadogia cienkowskii and determine the antiinflammatory properties of Fadogia cienkowskii. Method: the acute toxicity profile was evaluated using lorkes model, the antiinflammatory effect of the extract Fadogia cienkowskii (stem bark) was determined using the carrageenan induced paw edema and dextran induced paw edema models. Results: Oral administration of the extract produced no mortality and acute toxicity and also produced significant (p<0.05) antiedematogeni effect with the dose of 100,200 and 400mg/kg in the carrageenaninduced edema model. In the dextran-induced edema model significantly inhibited dextran-induced edema sustained through the experiment. Conclusion: The result indicates that ethanol extract of Fadogia cienkowskii stem bark has no potential for sure Toxicity and possess acute antiinflammatory activity mediated by either blocking release of
histamine and prostaglandins. Thus supporting the usage of the plant in traditional medicine treatment of inflammation.