SCHOOL OF BASIC MEDICAL SCIENCES, COLLEGE OF MEDICINE,

Parkia biglobosa (African locust beans) is a perennial plant, it's seed has been reported to have good organoleptic containing high levels of fat, crude protein, pure protein, carbohydrates and starch. The fermented seed of P.biglobosa has been reported to contain an increased level of nutrients and secondary metabolites such as protein, fat, carbohydrates, phenols, saponins, flavonoids as compared to the unfermented seed. In various studies p.biglobosa has been shown to have antiulcer, antioxidant, anti-inflammatory therapeutic properties. Aspirin is a salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID). Aspirin is used to reduce fever and relieve mild to moderate pain. Aspirin has been reported to have cardiovascular protective effect as well as adverse effects such as stomach ulcers and gastrointestinal bleeding. The aim of this study is to investigate fermented seed extract of Parkia biglobosa for its gastroprotective effect on aspirin induced gastrointestinal injury. Thirty male wistar rats where used for this study,which was divided into six groups having five rats per group (n=5). Animals in group one served as the unexposed group, groups two where fed 1000mg/kg of extract, group three where fed 20mg/kg of aspirin, group four, five and six were fed the extract and aspirin at alternated time frame. Histological changes as well as stomach weight, initial and final body weight were analyzed. Statistical softway SPSS version 20 was used to analyze the data obtained. The statistical results showed no significant difference in increased stomach and body weight at p value <0.05. In the histological analysis of the oesophagus, stomach, small intestine and large intestine, group one and two where normal, group three had inflammation as a result of the aspirin administered. In group four the various parts analyzed where normal which showed the counter effect of p.biglobosa. Group five and six had various parts still inflamed which could be as a result of increased dosage or the duration of administration. In conclusion, it maybe inferred that Parkia biglobosa has an effect, which is a counteracting effect on aspirin against gastrointestinal tract injury in male wistar rat.

Background: Artificial Intelligence (AI) is transforming global healthcare by enhancing diagnostics and clinical workflows. However, in resource-constrained settings like Nigeria, the integration of AI remains uneven, often hindered by infrastructure deficits and limited training. While awareness of AI is growing, there is a significant gap between knowledge and actual clinical implementation among healthcare professionals. Aim: The study aimed to assess the uptake and level of utilisation of artificial intelligence in clinical support among healthcare professionals at the University of Benin Teaching Hospital (UBTH). Specifically, it determined the level of knowledge, attitudes, and factors influencing AI adoption within the institution. Methods: An analytical cross-sectional study design was employed, involving 409 healthcare professionals including doctors, nurses, pharmacists, medical laboratory scientists, and physiotherapists. Participants were selected using a multistage sampling technique. Data were collected through structured, pre-tested, self-administered questionnaires comprising sections on socio-demographic characteristics, level of knowledge, attitude, uptake and level of utilisation,and factors influencing AI use. Knowledge, uptake and level of utilisation scores were categorized based on a 70% cut-off, while attitud was assessed using a 5-point likely scale which was grouped into appropriate and inappropriate responses and scored using a cut-off of 70%. Data were analyzed using IBM SPSS version 27.0. Descriptive and inferential statistics were used to identify predictors of AI uptake and utilisation. Statistical significance was set at p< 0.050, and 95% confidence interval. Results: Among the 409 healthcare professionals surveyed, the majority were aged 20–29 years(50.4%), female (63.3%), Christians (97.3%), and single (61.9%). Nurses constituted the largest professional group (47.4%), followed by doctors (39.9%), while most respondents were junior staff (55.7%) with less than 10 years of work experience (85.3%). All respondents (100%) were aware of AI, with 61.1% demonstrating good knowledge. While more than half (51.3%) had ever used an AI tool, predominantly ChatGPT, routine clinical utilisation remained low. Slightly more than half (51.1%) of the respondents expressed a negative attitude toward AI in clinical assessment. Positive attitudes (OR = 1.59; 95% CI: 1.034–2.447; p = 0.035) and higher educational qualifications (OR = 3.169; 95% CI: 1.040 9.651; p = 0.042) were significant predictors of AI uptake and utilisation. Major barriers identified included unclear ethical guidelines, patient’s attitude towards AI use, infrastructurallimitations (such as unstablepower and internet), and concerns regarding patient data privacy. However, patients’ attitude was the only significant predictor (p = 0.049) Conclusion: While healthcare professionals at UBTH have relatively high awareness and initial uptake of AI, sustained and routine utilisation remains constrained by negative attitudes and perceived patient’s attitude. These perceptions appear to shape hesitancy in fully integrating AI into clinical workflows. To address this, there is an urgent need for structured institutional training, clear ethical frameworks, and improved digital infrastructure to shift attitudes and support safe, routine and effective integration of AI into clinical practice. Keywords: Artificial Intelligence, Clinical Assessment, Healthcare Professionals, Uptake,Utilisation, UBTH, Nigeria

Deoxyribonucleic acid (DNA) testing has become an essential tool in resolving disputes of biological relationships, particularly maternity and paternity cases, with significant social, legal, and emotional implications. In Nigeria, cultural traditions, limited awareness, and socioeconomic challenges influence the acceptance and accessibility of DNA technology. This study therefore aimed to assess the perception and awareness of DNA testing for resolving maternal and paternal disputes among residents of Benin City, Edo State, Nigeria. A cross-sectional descriptive survey design was employed. A total of one hundred and fifty-one (151) adult residents of Benin City were recruited using a random sampling technique. Data were collected using a structured 22- item questionnaire covering demographics, awareness, knowledge, and perceptions of DNA testing. Responses were analyzed with the Statistical Package for Social Sciences (SPSS) version 26.0, using Chi-square tests with significance set at p < 0.05. The findings revealed that 86.7% of respondents had heard of DNA testing being used to resolve maternity and paternity disputes, but only 34.7% reported personal or second-hand involvement. While 83.3% correctly identified DNA testing as a method to confirm biological relationships, only 42.0% were aware of existing facilities in Benin City. Practical exposure was limited, as just 28.0% had visited or knew someone who had visited a DNA testing facility. Nonetheless, perceptions were largely positive, with 71.3% affirming that DNA testing could accurately resolve disputes, and 79.4% expressing willingness to learn more about its applications. Knowledge gaps persisted, as 39.3% believed external factors could affect accuracy, with laboratory error most frequently mentioned. In conclusion, this study revealed that awareness and positive perceptions of DNA testing are high among Benin City residents, but actual utilization and technical understanding remain limited. The results underscore the need for public education, expanded access to affordable DNA
facilities, and integration of counseling and ethical safeguards to enhance acceptance and prevent misuse. These findings highlight DNA testing’s potential as a reliable, culturally sensitive tool for resolving family disputes in Nigeria.