Oriakhi Kelly

Chasmanthera dependens is a plant known for its medicinal purposes. Liver diseases, especially those induced by toxins such as CCl4, continue to be a significant global health concern. This study was conducted to evaluate the effects of hydroethanol extract of Chasmanthera dependens on liver function test parameters in CCl4- induced toxicity. In this experimental study,25 male
Wistar rats were divided into five groups :Group 1 was a control group, Group 2 was a CCl4- treated group,Group 3 was a silymarin treated group of 140mg/kg, Group 4 and 5 were Chasmanthera dependens treated groups receiving different doses of the extract (250 and 500 mg/kg body weight) along with CCl4 induction. The rats were sacrificed after 2weeks of treatment and blood was collected to run the analysis. There was a significant increase (p<0.05) in liver function parameters total bilirubin, albumin, total protein, and in globulin concentration, there was no significant difference in conjugated biliburin concentration when compared to normal control group. The group receiving the highest dose of Chasmanthera dependens (500 mg/kg) showed an improvement in liver function parameters, total protein and albumin. In conclusion, the hydroethanol extract of Chasmanthera dependens exhibited hepatoprotective effects against CCl4-induced liver toxicity by preserving liver function test parameters particularly in terms of protein synthesis and maintaining blood protein levels. These findings suggest the potential therapeutic use of Chasmanthera dependens in protecting the liver from toxic insults and warrant further investigations into its underlying mechanisms of action.

There has been a notable increase in the use of herbal medicine over the past twenty years. Moreover, there is still a tremendous lap of proper research data in the field of traditional herbal medicine. Enantiachloranthais a plant belonging to the Annonacoae family. Its common name is Africa Yellow Wood. It contains some phytochemicals which confer anti-diabetic properties. The aim of this study is to evaluate the anti-diabetic and anti- inflammatory effects of Enantiachlorantha stem bark on STZ induced type 2 diabetes in adult wistar rats. Forty-nine (49)male Wister rats of 170-180g weight were used for this experiment. They were grouped into seven groups; Group 1 (Normal control), Group 2 (HFD+STZ), Group 3(HFD+STZ+ metformin 500mg/kg bwt), Group 4 (HFD +STZ+ 200mg/kg bwt crude hydro-ethanol extract), Group 5 (HFD + STZ+ 400mg/kg bwt crude hydroethanol extract), Group 6 (HFD + STZ+ 200mg/kg bwt ethyl-acetate fraction), Group 7 (HFD+STZ+ 400mg/kg bwt ethyl-acetate fraction). The results showed a marked decrease in blood glucose level in thr treated groups. Rats administered the extract crude and ethyl acetate fractions showed high expression of Nrf-2.In group 4, at 200 mg/kg body weight of thereextract crude and ethyl acetate fractions was increased activity of superoxide dismutase and catalase enzyme.This study concluded that Enantiachloranthahas positive anti-diabetic and anti- inflammatoryeffects.