ANTI-DIABETIC AND ANTI-OXIDANT ACTIVITIES OF Enantia chlorantha STEM BARK ON STREPTOZOTOCIN-INDUCED DIABETES ON THE LIVER OF ADULT WIST AR RATS FED ON HIGH FAT DIET

There has been a notable increase in the use of herbal medicine over the past twenty years. Moreover, there is still a tremendous lap of proper research data in the field of traditional herbal medicine. Enantiachloranthais a plant belonging to the Annonacoae family. Its common name is Africa Yellow Wood. It contains some phytochemicals which confer anti-diabetic properties. The aim of this study is to evaluate the anti-diabetic and anti- inflammatory effects of Enantiachlorantha stem bark on STZ induced type 2 diabetes in adult wistar rats. Forty-nine (49)male Wister rats of 170-180g weight were used for this experiment. They were grouped into seven groups; Group 1 (Normal control), Group 2 (HFD+STZ), Group 3(HFD+STZ+ metformin 500mg/kg bwt), Group 4 (HFD +STZ+ 200mg/kg bwt crude hydro-ethanol extract), Group 5 (HFD + STZ+ 400mg/kg bwt crude hydroethanol extract), Group 6 (HFD + STZ+ 200mg/kg bwt ethyl-acetate fraction), Group 7 (HFD+STZ+ 400mg/kg bwt ethyl-acetate fraction). The results showed a marked decrease in blood glucose level in thr treated groups. Rats administered the extract crude and ethyl acetate fractions showed high expression of Nrf-2.In group 4, at 200 mg/kg body weight of thereextract crude and ethyl acetate fractions was increased activity of superoxide dismutase and catalase enzyme.This study concluded that Enantiachloranthahas positive anti-diabetic and anti- inflammatoryeffects.