SYLVESTER ERAGA

Fast-disintegrating tablets (FDTs) are tablets designed to dissolve rapidly when placed on the tongue resulting in quick disintegration of the drug into solution when in contact with saliva. This study aimed to formulate and evaluate fast disintegrating tablets of
diclofenac potassium using different concentrations of sodium starch glycolate (SSG) and croscarmellose sodium (CCS) as superdisintegrants.

Co-processed excipients have been developed to enhance the performance of poorly soluble drugs like Glimepiride. Varying ratios of the API (Glimepiride) was mixed with the co-processed excipients and from the results, there was improved flowability, compressibility and disintegration properties, optimizing tablet formulation and bioavailability. Studies have demonstrated reduced lubricant sensitivity and enhanced drug release profiles. Co-processed excipients offer improved dilution potential, mechanical strength and faster manufacturing processes making co-procession a valuable advancement in pharmaceutical technology