B. O. GABRIEL

Traditional medicine encompasses manual therapies, exercises, and spiritual therapies in addition to medical therapies, theories, and practices that involve medications derived from plants, animals, and minerals. This investigation aims to assess the ability of Azanza garckeana in treating diarrhea in Swiss mice. Castor oil-induced diarrhea and gastrointestinal transit models in mice were used to assess the antidiarrheal effects of various dosages of the plant extract (25, 50, and 100 mg/kg). According to the study’s findings, the extract significantly (p < 0.05) reduced both the frequency of wet feces being defecated and the amount of feces produced overall when compared to the control group. In comparison to the untreated control, the extract triggered a substantial (p < 0.05) antimotility activity at higher doses. In conclusion, this study validated the ethnomedicinal report of Azanza garckeana as an efficacious anti-diarrhoea property, thereby required further study for compound elucidation and evaluation

The study aimed to evaluate the effects of biherbal leaf aqueous extract in Streptozotocin induced anaphrodisiac male Wistar rats. Thirty two Wistar rats were divided into six groups: a normal control group received 0.5ml/kg of distilled water, another group received gibenclamide
at 10mg/kg, the negative control received 50mg/kg of STZ, the treatment groups were divided into three each receiving 50, 100 and 200 mg/kg of the biherbal extract only for 28days. Mating
behaviour and testosterone levels were assessed. The results showed an increase in testosterone levels and mating behaviour of the albino rats when administered 50mg/kg and also showed that higher doses of the biherbal leaf extract had negative effects on the Wistar rats. The findings suggests that the combination of Alstonia boonei and Vernonia amygdalina has aphrodisiac properties without adverse effects on organ integrity making it a perfect candidate for further research as an aphrodisiac agent.

Diarrhoea is the excretion or passage of watery stools at least twice or three times within 24-hour. Traditional medicines are largely underused as a source of health care. Insights and innovative approaches from traditional medicine can also directly impact the economy and public health. The aim of this study is to evaluate the anti-diarrhoeal activity of Chrysobalanus icaco (coco plum) fruit methanol extract in Swiss mice. Diarrhoea was induced in Swiss mice using castor oil model. Parameters such as consistency, frequency, and duration of stool were investigated and compared with the control groups. The results obtained from this study showed that C. icaco fruit methanol extract elicited an inhibitory effect in castor oil induced diarrhoea across graded doses of the extract when compared with the untreated control. Also, a significant decrease in the number of diarrhoea compared with the untreated group p <0.05). In conclusion, the findings of this study demonstrated that C. icaco fruit methanol extract possessed a significant anti- diarrhoeal activity. However, further research is warranted to elucidate the underlying molecular mechanisms and to determine its long-term safety and efficacy in human subjects