PREVALENCE

This study examined the prevalence and causes of maternal mortality among women in Oredo Local Government Area of Edo State, Nigeria. Maternal mortality, defined as the death of a woman during pregnancy or within 42 days of the termination of pregnancy, remains one of the most critical public health challenges in developing nations, especially Nigeria. Despite national and global efforts to reduce maternal deaths through initiatives such as the Safe Motherhood Initiative, Millennium Development Goals (MDGs), and Sustainable Development Goals (SDGs), Nigeria continues to rank among the countries with the highest maternal mortality ratio (MMR) globally. The study adopted a descriptive survey research design, and data were collected from one hundred (100) women of reproductive age (15–45 years) selected through random sampling from various wards within Oredo Local Government Area. A structured questionnaire was the main instrument for data collection. The data were analyzed using descriptive statistics such as mean and standard deviation to interpret the responses according to the research questions. Findings revealed that maternal mortality in Oredo Local Government Area is influenced by both medical and non-medical factors. The major causes identified include lack of access to skilled birth attendants, poor nutrition, delay in seeking medical attention, cultural beliefs, and poor road infrastructure, with a grand mean of 3.30. The educational status of women also plays a significant role (grand mean = 3.24), as illiteracy and low awareness contribute to poor maternal health decisions. Income level emerged as a crucial determinant (grand mean = 3.58), as low-income women often cannot afford quality healthcare, leading to home deliveries and increased mortality. Similarly, deficiencies within the healthcare system such as shortage of qualified personnel, inadequate facilities, and poor emergency services were found to significantly enhance maternal mortality (grand mean = 3.17). The study concluded that maternal mortality in Oredo LGA results from an interplay of socio-economic, educational, cultural, and infrastructural factors. It therefore recommended improved investment in healthcare infrastructure, promotion of women’s education, economic empowerment initiatives, and stronger maternal health awareness campaigns. The study contributes to existing sociological and public health knowledge by emphasizing that maternal mortality is not only a medical issue but also a manifestation of broader social and structural inequalities that demand multidimensional interventions

This study examined the prevalence and pattern of psychoactive substance use among secondary school students in Benin Metropolitan Area, Edo State, Nigeria. A descriptive cross-sectional research design was adopted for the study. The target population consisted of senior secondary school students from selected public secondary schools, with a sample size of 331 respondents selected using simple random sampling technique. Data were collected using a self-structured questionnaire and analyzed using descriptive statistics and chi-square tests. Findings revealed that the prevalence of psychoactive substance use among the respondents was 15.4%, while the majority (84.6%) reported no history of substance use. The most commonly used substances identified were tramadol (6.3%), alcohol (6.0%), and codeine (3.0%). In terms of usage pattern, a higher proportion of students reported occasional use (6.3%), while others used substances daily or weekly (4.5% each). The study also showed that substances were mainly obtained from friends, schoolmates, and street vendors. The study concluded that psychoactive substance use exists among secondary school students in Benin Metropolis, with identifiable patterns and influencing factors. It is therefore recommended that schools, families, and government agencies strengthen preventive strategies through health education, counseling services, and stricter control of substance accessibility among adolescents.

An internally displaced person (IDP) is someone who is forced to leave his/her home due to a crisis, conflict, or natural disaster to find safety within their country's borders. Internal displacement has significant effects on public health, including the prevalence of typhoid fever. Following decades of several crises in Benue State, there has been an increasing number of internally displaced persons (IDPs). The aim of this study was to assess the prevalence of virulent and resistant genes of Salmonella typhi among internally displaced persons in two local government areas of Benue State, Nigeria. Four hundred (400) stool samples were collected alongside with a well-structured questionnaires, 200 stool samples were collected from each IDP camp (Logo and Guma). The samples were screened for Salmonella Typhi following standard bacteriological procedures. Salmonella isolates were subjected to antibiotic susceptibility test on Muller-Hinton agar following the Kirby-Bauer disk diffusion technique. Plasmid gel electrophoresis was used to screen the isolates for plasmids. Acridine orange was used for curing experiment. Polymerase chain reaction was used to detect virulent and resistant genes: inVA, FliC-d, tetA and blaTEM, respectively. The identification of Salmonella Typhi was done by using PCR the STY0307- specific gene primers. The results of this study showed a higher prevalence [50(12.5%)] of S. typhi infection in Logo LGA compared to Guma LGA, with 30(7.5%). Salmonella typhi infection was highest 5.0% amongst IDPs aged ≤10 years in Logo LGA and 3.0% in Guma LGA. Female IDPs had a significantly (P<0.05) higher prevalence rate (8.75%) in Logo LGA than males, with 3.75%. Female IDPs in Guma LGA had a higher infection rate 5.0% in comparison to males with 2.5%. Concerning duration in camps, IDPs who lived longer than 2years had a higher Salmonella Typhi infection rate (4.25% in Guma LGA and 9.5% in Logo LGA). Salmonella Typhi isolates exhibited resistance to ceporex (cephalexin), ciprofloxacin (cipro), ampicillin (omnipen), streptomycin (trobicin), gentamycin (gentamicin) and tetracycline (doxycycline). The isolates' multiple antibiotic resistance index (MARI) ranges from 0.4 to 0.7. The study demonstrated a high prevalence of plasmid mediated multidrug resistant potentially virulent strains of xvii Salmonella Typhi amongst the sample IDP dwellers. The antibiotic resistance was borne on lasmids following the post-curing experimentation. The isolates showed presence of the blaTEM resistant gene of 100.00% isolates and tetA resistant gene 50.00% isolates. Polymerase chain reaction analysis revealed that 80% of the isolates harboured the inVA gene. The FliC-d virulent gene was not detected in the isolates. A total of 75.00% of the isolates showed amplification of the STY0307 gene, for Salmonella Typhi. The presence of typhoid fever and high levels of antimicrobial resistance plasmid-mediated in this study implies a significant threat to public health. It is therefore imperative for stakeholders and policymakers to prioritize healthcare infrastructure, routine screening, and education within IDP settings to curb the spread of resistant and virulent S. typhi strains.