P.O UADIA

Andrographis paniculata can be found in different environment ranging from plains, hill, slopes or even road sides and it is grown annually mostly in western asia. It is widely used in the treatment of disease such as sore throat, liver disease, gastrointestinal infection etc. It is characterized by it's bitter taste which is known to contribute to its name " The king of bitters". The aim of this research was to observed and determine the effect of aqueous extract of Adrographic paniculata on the activity of lipase, GGT and GPx on streptozotocin induced rat. The results of this study showed that Andrographis paniculata has potent therapeutic potential and could be used in the treatment of diabetes.

A branching, annual plant with lance-shaped green leaves that grows to a height of 60 to 70 cm, Andrographis paniculata is an example of this (Mishra et al, 2007).( Kabeeruddin & Kitabul,1937) wrote in their journal that in Asian nations including India, Sri Lanka, Pakistan, Java, Malaysia, and Indonesia are among those where it thrives frugally. The name Kalmegh is the most popular one in India. One of the widely employed medicinal herbs in the country, and it may be found in the plains. Additionally, the plant is referred to as the “king of bitters”( Kabeeruddin & Kitabul,1937; Shahid, 2011). Since the entire plant, including the leaves, has a very bitter flavor. It has a long history of medicinal use In conventional Chinese, Indian, and Ayurvedic medicine, as well as Western medicine