THE COMPARATIVE EFFECT OF THE ADMINISTRATION OF HYDRO-METHANOL 25MG/KG AND ACETONE-FRACTION 25MG/KG ON GAMMA-GLUTAMYL TRANSFERASE ACTIVITY OF L- NAME STREPTOZOTOCIN INDUCED HYPERTENSIVE / DIABETIC MALE WISTAR RAT.
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Hypertension and diabetes are associated with metabolic disturbances, including abnormal enzyme activity that can contribute to disease progression. This study evaluates the therapeutic potential of Simarouba glauca extracts in modulating gamma- glutamyl transferase (GGT) activity in hypertensive and diabetic rats. Both hydro- methanol and acetone fractions exhibited a significant ability to restore GGT activity in blood plasma and liver tissue, indicating their dual role in metabolic regulation and hepatoprotection. The acetone fraction demonstrated slightly superior effects, likely due to its distinct phytochemical composition, which may include a higher concentration of bioactive compounds. The ability of these extracts to normalize GGT activity suggests they possess antioxidant properties that contribute to enzyme stabilization and liver protection. These findings highlight the potential of Simarouba glauca as a natural therapeutic agent for managing metabolic dysfunctions associated with hypertension and diabetes. Further research is needed to elucidate the precise bioactive constituents responsible for these effects and their mechanisms of action
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