intraocular pressure

Diabetes mellitus has been increasingly linked with ocular complications, particularly elevated intraocular pressure (IOP), a key risk factor for glaucoma. Understanding the relationship between blood sugar level and Intraocular pressure is critical for early detection and prevention of vision-threatening conditions. This study aimed to determine the relationship between fasting blood sugar (FBS) levels and intraocular pressure and assess the influence of age and gender on these parameters among adults in Benin City, Nigeria. A cross-sectional study was conducted among 100 adults aged 41–80 years with the mean age (61.5 years) attending St. Teresa Specialist and Laser Eye Center, Benin City. Fasting blood sugar was measured using a glucometer, and intraocular pressure was assessed using an iCare tonometer. Statistical analyses were performed using SPSS version 22, applying t-tests, ANOVA, and Pearson correlation. The findings revealed a strong positive correlation between fasting blood sugar and intraocular pressure (r = 0.658, p = 0.01). Males exhibited higher mean IOP (17.44 mmHg) than females (15.49 mmHg; p = 0.047), while older age groups (61–80 years) showed significantly higher FBS (126.84 mg/dl) and IOP (18.72 mmHg) values compared to younger participants (p < 0.05). It is concluded from this study that elevated fasting blood sugar is significantly associated with increased intraocular pressure, with age and gender acting as modifying factors. Routine IOP screening is recommended for individuals with elevated blood glucose, regardless of diabetic status.

Non-communicable diseases like high blood pressure, diabetes, and glaucoma cause serious health issues and hardships in sub-Saharan Africa, often made worse by a lack of access to regular medical services. This research examines how the leaf extracts from Sorghum bicolor and Andrographis paniculata affect blood pressure, blood sugar, and eye pressure in healthy adults, both separately and together. One hundred and seventy-four (174) participants (mean age 34.3 ± 7.1 years) received single administrations of hot aqueous extracts of S. bicolor, A. paniculata, or a 1:1 mixed extract. Systolic and diastolic blood pressure (mmHg), fasting blood glucose (mg/dL) and IOP (mmHg, right eye [RE] and left eye [LE]) were measured at baseline and four hours post- administration. The results revealed statistically significant reductions (p < 0.05) across all parameters in all treatment groups. For Sorghum bicolor, systolic pressure decreased from 126.15 ± 15.9 to 120.80 ± 15.0 mmHg, diastolic pressure from 85.60 ± 11.1 to 80.03 ± 10.4 mmHg, blood glucose from 82.86 ± 14.61 to 70.39 ± 11.99 mg/dL, and IOP from 16.88 ± 2.5 to 15.83 ± 1.6 mmHg (right eye) and from 17.14 ± 1.93 to 16.12 ± 1.8 mmHg (left eye). Similar reductions were observed with Andrographis paniculata, where systolic pressure fell from 129.44 ± 14.7 to 121.20 ± 16.9 mmHg, diastolic pressure from 84.60 ± 13.3 to 77.13 ± 11.4 mmHg, and blood glucose from 83.61 ± 13.2 to 75.26 ± 11.43 mg/dL, while IOP decreased to 14.49 ± 2.0 mmHg (right) and 15.98 ± 2.0 mmHg (left). The combined extract produced the greatest effect, with systolic pressure reducing from 134.63 ± 15.7 to 128.68 ± 15.9 mmHg, diastolic pressure from 87.10 ± 22.1 to 77.90 ± 12.2 mmHg, blood glucose from 80.42 ± 12.04 to 74.40 ± 10.20 mg/dL, and IOP from 15.94 ± 1.8 to 14.94 ± 2.0 mmHg (right) and 15.67 ± 1.5 to 15.13 ± 2.7 mmHg (left). These results demonstrate that both Sorghum bicolor and Andrographis paniculata extracts—singularly and in combination—can significantly lower blood pressure, blood glucose, and intraocular pressure within a short period following administration. The enhanced effects observed with the combined extract suggest possible synergistic interactions between their phytochemical constituents.

Background: Intraocular pressure (IOP) is a key physiological parameter that maintains the structural integrity of the eye and plays a critical role in the pathogenesis of glaucoma. Although normal IOP values are well established in adults, there remains limited data regarding its distribution and influencing factors among children in Nigeria. This study aimed to assess the
distribution of intraocular pressure among school-aged children in Benin City, Nigeria, and to evaluate variations in relation to age, gender, and body mass index (BMI). Data Analysis: A cross-sectional design was adopted, involving 568 children aged 6–14 years selected from public and private schools in Benin City through stratified random sampling. Ethical approval and
informed consent were obtained prior to participation. Data were collected using a structured form and IOP was measured with a non-contact tonometer. Anthropometric parameters were recorded to calculate BMI. Statistical analyses, including descriptive statistics, Spearman’s rank correlation, and the Mann–Whitney U test, were conducted using SPSS version 26, with significance set at p < 0.05. Results: results showed a mean IOP of 17 ± 2 mmHg, with values ranging between 14 and 21 mmHg. A strong positive correlation was observed between IOP and age (Spearman’s rho = 0.827, p < 0.001), while a moderate positive correlation was found between IOP and BMI (Spearman’s rho = 0.633, p < 0.001). There was also a statistically significant difference in IOP between male and female participants (p = 0.027). Conclusion: The study concludes that Nigerian children demonstrate IOP distributions consistent with international findings, but population-specific reference values are required for accurate clinical
assessment.