Glutathione

Asthma is a chronic inflammatory disease of the airways characterized by recurring episodes of wheezing, coughing, chest tightness, and shortness of breath. Oxidative stress plays a crucial role in the pathogenesis of asthma. This study aimed to investigate the effects of Synclisia Scabrida (Meirs) on reduced glutathione (GSH) and malondialdehyde (MDA) levels in lungs tissue of wistar rats with ovalbumin-induced asthma. Twenty (20) female wistar rats were divided into three subgroups and treated with ovalbumin-induced asthma for three weeks (21 days) followed by administration of Synclisia Scabrida (Meirs) at 0.4ml daily. The result showed that the extract significantly increased Glutathione (GSH) levels and decreased Malondialdehyde (MDA) levels in the lung tissue of treated rats compared to control groups. These findings suggests that Synclisia Scabrida (Meirs) has antioxidant properties and may be a potential therapeutic agent for the treatment of asthma. The study provides new insights into the role of oxidative stress in asthma and potential benefits of using natural products in the management of the disease.

Arsenic exposure remains a major environmental health concern due to its ability to generate oxidative stress and induce tissue injury, particularly in the liver. This study investigated the protective potential of rutin against sodium arsenite-induced hepatic oxidative damage in Wistar rats. The experiment involved the administration of sodium arsenite to induce oxidative stress,
while rutin was concurrently given at different doses to evaluate its antioxidant and hepatoprotective effects. Following treatment, liver antioxidant status was assessed through the measurement of key biochemical parameters including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Histopathological examination of liver tissues was also carried out to determine structural alterations associated with arsenite toxicity and the possible protective influence of rutin. The results indicated that exposure to sodium arsenite caused a pronounced decline in endogenous antioxidant defenses, reflected by reduced levels of GSH and decreased activities of SOD, CAT, and GPx. These biochemical disruptions were accompanied by noticeable histological abnormalities in hepatic tissue, suggesting oxidative damage and cellular
degeneration. However, rats that received rutin alongside sodium arsenite demonstrated marked improvement in antioxidant enzyme activities and glutathione levels compared with animals treated with arsenite alone. The degree of improvement was more pronounced at higher rutin doses, indicating a dose-dependent protective effect. The findings suggest that rutin exerts significant antioxidant activity capable of counteracting arsenite-induced oxidative stress in the liver. This protective action may be attributed to its ability to scavenge reactive oxygen species and enhance endogenous antioxidant defense mechanisms.
onsequently, rutin may serve as a promising natural compound for reducing oxidative damage associated with heavy metal toxicity. In conclusion, the study demonstrates that rutin effectively mitigates sodium arsenate-induced hepatic oxidative injury in Wistar rats by restoring antioxidant balance and improving liver tissue integrity.