REDUCED GLUTATHIONE (GSH) AND MALONDIALDEHYDE (MDA) LEVELS IN THE LUNG TISSUE OF WISTAR RATS MODEL OF OVALBUMIN-INDUCED ASTHMA TREATED WITH SYNCLISIA SCABRIDA (MEIRS)

Asthma is a chronic inflammatory disease of the airways characterized by recurring episodes of wheezing, coughing, chest tightness, and shortness of breath. Oxidative stress plays a crucial role in the pathogenesis of asthma. This study aimed to investigate the effects of Synclisia Scabrida (Meirs) on reduced glutathione (GSH) and malondialdehyde (MDA) levels in lungs tissue of wistar rats with ovalbumin-induced asthma. Twenty (20) female wistar rats were divided into three subgroups and treated with ovalbumin-induced asthma for three weeks (21 days) followed by administration of Synclisia Scabrida (Meirs) at 0.4ml daily. The result showed that the extract significantly increased Glutathione (GSH) levels and decreased Malondialdehyde (MDA) levels in the lung tissue of treated rats compared to control groups. These findings suggests that Synclisia Scabrida (Meirs) has antioxidant properties and may be a potential therapeutic agent for the treatment of asthma. The study provides new insights into the role of oxidative stress in asthma and potential benefits of using natural products in the management of the disease.