R. I. NIMENIBO-UADIA

The present study was undertaken to investigate the effect of aqueous extract of Cymbopogon citratus on blood glucose, body weight and liver, kidney and pancreas reduced glutathione levels on normal and streptozotocin-induced diabetic rats. Diabetes mellitus was induced in the animals (diabetic control and diabetic treated), by intraperitoneal injections of streptozotocin (45mg/body weight), while the control groups received equal volume of the citrate buffer (pH 4.5) solution intraperitoneally. Streptozotocin treatment significantly increased (p < 0.05) blood glucose concentration in the diabetic rats compared to the normal rats. The normal treated and diabetic treated rats were given Cymbopogon citratus extract for 21 days (400mg/body weight). The pancreas, livers, and kidneys of the rats were excised and biochemical assay of reduced glutathione was determined. There was a significant (p < 0.05) decrease in the fasting blood glucose levels of the normal treated rats when compared with the normal control rats at the end of the 21 days treatment period. Levels of blood glucose in the diabetic rats were significantly increased (p<0.05) compared to the normal control rats. However, levels of blood glucose in the diabetic treated rats were not significantly different (p>0.05) when compared to the diabetic control rats. There was a significant decrease (p<0.05) in body weight in the diabetic rats when compared to the normal control rats. There was no significant % weight (p>0.05) gain in the diabetic treated rats when compared to the diabetic control rats and also there was a non- significant (p>0.05) decrease in weight in the normal treated rats when compared to the normal control rats. In the liver and the pancreas, the results for reduced glutathione concentration showed that there was no significant difference (p > 0.05) in the normal treated rats when compared to the normal control rats, in the diabetic control rats when compared to the normal control rats and in the diabetic treated rats when compared to the diabetic control rats. In thekidney, there was no significant difference observed (p>0.05) when the normal treated rats were compared with the normal control rats and when the diabetic treated rats were compared with thenormal control rats. However, when the diabetic treated rats were compared with the diabeticcontrol rats, there was a significant difference (p<0.05). Cymbopogon citratus does have somehypoglycemic and antioxidant properties but further research is needed to ascertain these claims.

Justicia carnea, commonly known as Brazilian plume or Jacobinia is a tropical flowering plant from the Acanthaceae family, it is traditionally used for it’s therapeutic properties. This study presents a meticulous proximate analysis, qualitative and qualitative phytochemical screening, mineral and vitamin C analysis obtained from Justicia carnea leaf. The Proximate analyses revealed high level of carbohydrate (57.16 ± 0.15%) and fibre (12.75 ± 0.11%) and moderate protein and ash content of (10.18 ± 0.10%) and (7.12 ± 0.09%) respectively, low level of fat (4.45 ± 0.08%) highlighting the plant’s nutritional value. The Phytochemical screening indicated that Ethanolic extracts were more efficient in extracting compounds such as Alkaloids, Flavonoids, Saponins Phenols and Terpenoids compared to Aqueous extracts. The high level of these secondary metabolites indicate the significant bioactivity of the plant. Quantitative analysis showed significant concentration of Polyphenones (65.20 ± 2.10%), Vitamin C (28.45 ± 0.86%) and moderate level of Phytic acid (10.04 ± 0.40%), which underscores the leaf’s antioxidant potentials. Mineral analysis identified Calcium and Iron as predominant elements. This lays a robust foundation for further exploration of the Justicia carnea leaf extract in pharmaceutical and nutraceutical applications, emphasizing it’s potential as a natural source of health promoting compound.

The present study was undertaken to investigate the effect of aqueous extract of Cymbopogon citratus on blood glucose, body weight and liver, kidney and pancreas reduced glutathione levels on normal and streptozotocin-induced diabetic rats. Diabetes mellitus was induced in the animals (diabetic control and diabetic treated), by intraperitoneal injections of streptozotocin (45mg/body weight), while the control groups received equal volume of the citrate buffer (pH 4.5) solution intraperitoneally. Streptozotocin treatment significantly increased (p < 0.05) blood glucose concentration in the diabetic rats compared to the normal rats. The normal treated and diabetic treated rats were given Cymbopogon citratus extract for 21 days (400mg/body weight). The pancreas, livers, and kidneys of the rats were excised and biochemical assay of reduced glutathione was determined. There was a significant (p < 0.05) decrease in the fasting blood glucose levels of the normal treated rats when compared with the normal control rats at the end of the 21 days treatment period. Levels of blood glucose in the diabetic rats were significantly increased p<0.05) compared to the normal control rats. However, levels of blood glucose in the diabetic treated rats were not significantly different (p>0.05) when compared to the diabetic
control rats. There was a significant decrease (p<0.05) in body weight in the diabetic rats when compared to the normal control rats. There was no significant % weight (p>0.05) gain in the
diabetic treated rats when compared to the diabetic control rats and also there was a non- significant (p>0.05) decrease in weight in the normal treated rats when compared to the normal control rats. In the liver and the pancreas, the results for reduced glutathione concentration showed that there was no significant difference (p > 0.05) in the normal treated rats when compared to the normal control rats, in the diabetic control rats when compared to the normal control rats and in the diabetic treated rats when compared to the diabetic control rats. In the kidney, there was no significant difference observed (p>0.05) when the normal treated rats were compared with the normal control rats and when the diabetic treated rats were compared with the normal control rats. However, when the diabetic treated rats were compared with the diabetic control rats, there was a significant difference (p<0.05). Cymbopogon citratus does have some hypoglycemic and antioxidant properties but further research is needed to ascertain these claims.

Standard analytical methods were utilized to investigate the nutritional composition and phytochemical content of Lantana camara Linn. leaves in order to uncover the plant's potential bioactive compounds and nutritional profile.. The qualitative phytochemical screening of the aqueous extract of Lantana camara Linn. leaves revealed the presence of various compounds such as tannins, flavonoids, alkaloids, cardiac glycosides, saponins, steroids, terpenoids, phlobatannins, coumarins, and proteins, with tannins being particularly abundant. However, phenols, anthraquinones, emodins, and anthocyanins were not detected. The composition of the ethanol extract showed variations, with flavonoids, alkaloids, tannins, cardiac glycosides, saponins, steroids, terpenoids, phlobatannins, coumarins, and proteins present in moderate amounts, while phenols, anthraquinones, emodins, and anthocyanins were still absent. The medicinal properties of Lantana camara Linn. are influenced by the presence and levels of these secondary metabolites. Proximate analysis revealed that Lantana camara Linn. leaves are rich in carbohydrates (26.59± 1.86%), have a high moisture content (18.00 ± 1.63%), crude protein (18.41 ± 0.02%), crude fats (17.33 ± 0.14%), crude fiber (10.00 ± 0.82%), and ash (9.67 ± 0.27%). The significant presence
of carbohydrates, protein, crude lipids, and fiber in the leaves may contribute to their nutritional value

Alstonia boonei De wild is a plant belonging to the Aponcyanacea family. Its leaves, root bark and stem bark parts have various traditional uses in parts of West Africa for the management of some ailments such as: Malaria, hypertension and cancer. The nutritional composition and phytochemical content of the leaf of Alstonia boonei De wild were explored under standard analytical methods in order to ingress the numerous potential of the plant. The qualitative phytochemical screening of aqueous extract of Alstonia boonei De wild, leaves showed the presence of saponins, tannins, alkaloids, phenols, steroids, cardiac glycosides, coumerins, phlobatannins and protein; with saponins, tannins, steroids, and phenol highly present. Flavanoids, terpenoids, emotins, anthraquinones and anthocyanins were seen to be absent. Variation of this composition was observed in the ethanol extract which showed that saponins, phenols, terpenoids, steroids, alkaloids, protein and anthocyanins were seen to be present in moderate proportion, whereas flavonoids, phlobatannins,coumerin, emotins and anthraquinones were seen to be absent, while cardiac glycosides was highly present. The medicinal value of Alstonia boonei De wild is influenced by the presence and levels of these secondary metabolites. The proximate analysis revealed that Alstonia boonei leaves are rich in carbohydrates (57.45 ± 1.38%), have a moderate content of Ash (3.67± 0.16%), crude protein (8.05 ± 00.05%), crude fats (9.50 ± 0.24%), and crude fibre (11.00 ± 0.47%); but a moderate content of moisture (10.30 ± 0.27%). The presence of high carbohydrates, protein, crude fats and fibre contents of the leaves may be responsible for their nutritive values