SPONDIAS MOMBIN

This study investigated the effect of Spondias mombin extract on selected haematological indices in a type 2 diabetic rat model. Diabetes induction produced notable hematological disturbances, characterized by reductions in haemoglobin concentration (HGB), haematocrit (HCT), and red blood cell (RBC) count relative to the normal control group. These declines reflect the oxidative and metabolic stress typically associated with chronic hyperglycaemia. Administration of Spondias mombin at doses of 200 mg and 400 mg produced a clear restorative effect on all parameters assessed. HGB and HCT values in the treated groups increased markedly approaching or surpassing normal baseline levels while RBC counts also improved substantially compared with the diabetic control. The magnitude of recovery observed was comparable to the positive control group, suggesting that S. mombin possesses potent hematoprotective activity. The observed effects are likely attributable to the plant’s rich phytochemical profile, including antioxidants and anti-inflammatory compounds, which collectively enhance erythrocyte stability, promote erythropoiesis, and counter oxidative stress. Overall, the findings indicate that Spondias mombin extract effectively mitigates diabetes-induced haematological alterations and may serve as a promising natural adjunct in the management of diabetic complications.

This study investigated the effects of methanol extract of Spondias mombin on body weight changes and liver histology in high-fat diet-fed rats. Obesity and metabolic disorders caused by high-fat diets are major global health concerns, prompting the search for safer plant-based therapeutic alternatives. In this study, thirty male Wistar rats were divided into five groups: a normal control group, a high-fat diet (HFD) control group, and three treatment groups administered 200 mg/kg, 400 mg/kg, and 600 mg/kg of Spondias mombin methanol extract respectively. The experiment lasted for six weeks, after which body weight and liver histological changes were assessed. Results showed that rats fed with a high-fat diet without treatment recorded the highest body weight gain (48.6%), confirming the successful induction of obesity. However, rats treated with the plant extract showed a significant and dose-dependent reduction in weight gain, with percentage gains of 32.9%, 30.0%, and 20.6% for the low, medium, and high doses respectively. Histological analysis of liver tissues revealed severe hepatic steatosis in the untreated HFD group, while extract-treated groups showed progressive improvement in liver structure, with the high-dose group exhibiting near-normal hepatic architecture and minimal fat accumulation. The findings suggest that methanol extract of Spondias mombin possesses significant anti-obesity and hepatoprotective properties and may serve as a potential natural therapeutic agent for managing diet-induced metabolic disorders.