PLASMID CURING OF RESISTANT BACTERIA

The control of infectious diseases is badly endangered by the rise in the number of micro organisms that are resistant to antimicrobial agents. This is because infections caused by resistant microorganisms often fail to respond to conventional treatment, resulting in prolonged illness and greater risk of death. The antibiotics susceptibility pattern of clinical isolates obtained from University of Benin Teaching Hospital was determined by Kirby Bauer disc diffusion method. The bacteria isolates obtained were S. aureus, S. epidermidis, S. hominis, E. coli andK. pneumonia. All test isolates were susceptible to Levofloxacin and Chloramphenicol. Corynebacterium jeikeium showed resistance to Streptomycin and Amoxicillin, K. pneumonia showed resistance to Norfloxacin. All S. epidermidis, showed no resistance to any of the antibiotics tested likewise E. coli and S. aureus. The multiple antibiotics resistance index of bacteria isolates revealed Corynebacterium jeikeium had an index of 0.2 which is the limit, K. pneumonia had an index of 0.1 and other were zero indicating these isolates do not pose threat to public health as they are not multidrug resistant and as such, plasmid curing was not carried out on these bacteria isolates.