NOSA-EDEGBE PRISCILLIA UWA

Colorectal cancer (CRC) remains a major global health challenge characterized by high incidence and mortality rates. Emerging evidence supports the use of plant-derived bioactive compounds as promising agents in cancer therapeutics. This study aimed to assess the anticancer potential of phytoconstituents from Moringa oleifera, Olea europaea, Brassica oleracea, and Vitis vinifera against key colorectal cancer protein targets using in silico methods. Phytochemical constituents from these plants were compiled from literature and chemical databases, with their three-dimensional structures retrieved from PubChem. Target proteins implicated in colorectal carcinogenesis, including Human Thymidylate Synthase enzyme, 1HVY, and epidermal growth factor receptor (EGFR), 1XKK, were prepared for docking using Biovia discovery studio. Molecular docking simulations were performed with AutoDock Vina in PyRx, evaluating binding affinities and ligand interactions at active sites. Post-docking analysis and ADMET predictions were done using Biovia discovery studio and ADMETLAB, respectively.