BIOLOGICAL EFFECT OF THE BIHERBAL FORMULATIO OF Irvingia gabonensis and Ocimum gratissimum ON INDUCED DIABETIC IN ALBINO RATS
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Abstract
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia and associated complications such as dyslipidemia and organ dysfunction. The limitations of synthetic anti-diabetic agents and their side effects have heightened interest in medicinal plants. This study investigated the hypoglycemic and anti-diabetic potentials of the leaves of Irvingia
gabonensis (Bush mango) and Ocimum gratissimum in normoglycemic and Streptozotocininduced diabetic Wistar rats. Ethanol extract of the combined leaves of Irvingia gabonensis and Ocimum gratissimum was obtained through cold maceration and subjected to acute toxicity and efficacy studies. No signs of toxicity were observed at doses up to 5000 mg/kg, suggesting a
wide safety margin. The extracts significantly reduced blood glucose levels, improved lipid profiles by lowering triglycerides, LDL, and total cholesterol while increasing HDL, and restored liver function markers (AST, ALT, ALP, and total protein) towards normal values. These effects were comparable to glibenclamide, a standard Antidiabetic drug. These findings provide scientific evidence supporting the ethno medicinal use of Irvingia gabonensis and Ocimum gratissimum in diabetes management. This study concludes that these plants exhibit potent anti- diabetic properties, and may serve as safe, natural alternatives or complementary therapies for diabetes and related complicationDiabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia and associated complications such as dyslipidemia and organ dysfunction. The limitations of synthetic anti-diabetic agents and their side effects have heightened interest in medicinal plants. This study investigated the hypoglycemic and anti-diabetic potentials of the leaves of Irvingia gabonensis (Bush mango) and Ocimum gratissimum in normoglycemic and treptozotocininduced diabetic Wistar rats. Ethanol extract of the combined leaves of Irvingia gabonensis and Ocimum gratissimum was obtained through cold maceration and subjected to acute toxicity and efficacy studies. No signs of toxicity were observed at doses up to 5000 mg/kg, suggesting a wide safety margin. The extracts significantly reduced blood glucose levels, improved lipid profiles by lowering triglycerides, LDL, and total cholesterol while increasing HDL, and restored liver function markers (AST, ALT, ALP, and total protein) towards normal values. These effects were comparable to glibenclamide, a standard Antidiabetic drug. These findings provide scientific evidence supporting the ethno medicinal use of Irvingia gabonensis and Ocimum gratissimum in diabetes management. This study concludes that these plants exhibit potent anti- diabetic properties, and may serve as safe, natural alternatives or complementary therapies for diabetes and related complication
gabonensis (Bush mango) and Ocimum gratissimum in normoglycemic and Streptozotocininduced diabetic Wistar rats. Ethanol extract of the combined leaves of Irvingia gabonensis and Ocimum gratissimum was obtained through cold maceration and subjected to acute toxicity and efficacy studies. No signs of toxicity were observed at doses up to 5000 mg/kg, suggesting a
wide safety margin. The extracts significantly reduced blood glucose levels, improved lipid profiles by lowering triglycerides, LDL, and total cholesterol while increasing HDL, and restored liver function markers (AST, ALT, ALP, and total protein) towards normal values. These effects were comparable to glibenclamide, a standard Antidiabetic drug. These findings provide scientific evidence supporting the ethno medicinal use of Irvingia gabonensis and Ocimum gratissimum in diabetes management. This study concludes that these plants exhibit potent anti- diabetic properties, and may serve as safe, natural alternatives or complementary therapies for diabetes and related complicationDiabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia and associated complications such as dyslipidemia and organ dysfunction. The limitations of synthetic anti-diabetic agents and their side effects have heightened interest in medicinal plants. This study investigated the hypoglycemic and anti-diabetic potentials of the leaves of Irvingia gabonensis (Bush mango) and Ocimum gratissimum in normoglycemic and treptozotocininduced diabetic Wistar rats. Ethanol extract of the combined leaves of Irvingia gabonensis and Ocimum gratissimum was obtained through cold maceration and subjected to acute toxicity and efficacy studies. No signs of toxicity were observed at doses up to 5000 mg/kg, suggesting a wide safety margin. The extracts significantly reduced blood glucose levels, improved lipid profiles by lowering triglycerides, LDL, and total cholesterol while increasing HDL, and restored liver function markers (AST, ALT, ALP, and total protein) towards normal values. These effects were comparable to glibenclamide, a standard Antidiabetic drug. These findings provide scientific evidence supporting the ethno medicinal use of Irvingia gabonensis and Ocimum gratissimum in diabetes management. This study concludes that these plants exhibit potent anti- diabetic properties, and may serve as safe, natural alternatives or complementary therapies for diabetes and related complication
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