DAVID JACOB PRECIOUS ALEKOSE

Nickel chloride is known for its neurotoxicity and its exposure poses significant threat to the cerebrum, an essential brain organ for a lot of human day to day activities. This study investigates the neuroprotective effects of vitamin B6 on the cerebral integrity in nickel chloride exposed Wistar rats. After acclimatization for 14 days, fourty-one rats were weighed and divided to six groups of (n = 7). Group A (control) was administered 1ml of distilled water. Group B (NiCl2) was administered 5mg/kg body weight (BW) of Nickel chloride only. Group C (Citicoline-1) was administered 25mg/kg BW of vitamin B6 only. Group D (Citicoline-2) was administered 50mg/kg BW of vitamin B6 only. Group E (NiCl2+ Citicoline-1) was administered 25mg/kg BW of vitamin B6 and 5mg/kg BW of Nickel chloride. Group F (NiCl2 + Citicoline-2) was administered 50mg/kg BW of vitamin B6 and 5mg/kg BW of Nickel chloride.