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Abstract
This study used mouse models to assess the acute toxicity and analgesic effects of Moringa oleifera extract. Acute toxicity was tested by giving different oral dose up to 5000 mg/kg, which resulted in no mortality, showing relative safety. The analgesic efficacy was assessed using acetic acid-induced writhing and formalin-induced paw licking assays. The extract considerably reduced writhing behaviors in a dose-dependent manner (p < 0.05), indicating peripheral analgesic effects. In the formalin test, the extract significantly reduced paw licking time in both neurogenic (early) and inflammatory (late) phases, with significant effects at moderate and high dosages (p < 0.05), indicating wide analgesic and antiinflammatory activities. These data confirm Moringa oleifera extract's potential as a safe and effective analgesic agent. Moringa oleifera's phytochemical components, which include flavonoids, alkaloids, saponins, tannins, and phenolic acids, are thought to work together to provide analgesic and anti-inflammatory benefits. The extract's ability to attenuate nociceptive behaviors in established experimental models backs up its longstanding use in folk medicine to treat pain and inflammation. The findings of this work give experimental confirmation for Moringa oleifera root bark as a promising natural analgesic with a wide range of efficacy, prompting further investigation into its pharmacological mechanisms and possible clinical applications. The extract's analgesic efficacy and safety profile make it a promising lowrisk pain management option
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