THE EFFECT OF METHANOL EXTRACT OF Spondias mombin LEAVES ON TOTAL CHOLESTEROL AND TRIGLYCERIDE LEVEL IN HIGH-FAT DIET FED RATS
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Abstract
Hyperlipidemia, a major risk factor for cardiovascular diseases, is often managed with conventional lipid-lowering drugs that may have adverse effects. This study investigates the effects of methanol extract of Spondias mombin on total cholesterol and triglyceride levels in high-fat diet-fed rats. Experimental groups- group three, group four and group five received
different doses of the extract, while controls- positive control (group 1) and negative control (group 2) remained untreated. Biochemical analysis revealed a significant reduction in total cholesterol and triglycerides in treated rats, suggesting potent hypolipidemic effects (p<0.05). The observed lipid-lowering activity may be attributed to phytochemicals such as flavonoids,
tannins, and saponins, which regulate lipid metabolism and possess antioxidant properties. These findings highlight Spondias mombin as a promising natural alternative for hyperlipidemia management, warranting further research on its mechanisms and clinical applications
different doses of the extract, while controls- positive control (group 1) and negative control (group 2) remained untreated. Biochemical analysis revealed a significant reduction in total cholesterol and triglycerides in treated rats, suggesting potent hypolipidemic effects (p<0.05). The observed lipid-lowering activity may be attributed to phytochemicals such as flavonoids,
tannins, and saponins, which regulate lipid metabolism and possess antioxidant properties. These findings highlight Spondias mombin as a promising natural alternative for hyperlipidemia management, warranting further research on its mechanisms and clinical applications
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