Pseudomonas aeruginosa ISOLATED

Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen of major clinical concerndue to its adaptability, virulence determinants, and increasing multidrug resistance (MDR). It isaleading cause of urinary tract infections, pneumonia, wound infections, and septicemia, particularly in hospitalized and immunocompromised patients. Its resistance mechanisms includeintrinsic traits such as efflux pumps and β-lactamase production, acquired carbapenemases, andadaptive tolerance via biofilm formation, making it one of the World Health Organization’scritical priority pathogens. This cross-sectional study was conducted at the University of BeninTeaching Hospital (UBTH) to evaluate the antibiotic resistance profile of Pseudomonasaeruginosa across clinical specimens. The clinical isolates collected were processedusingstandard microbiological and biochemical techniques. Susceptibility testing was done, withresults interpreted using CLSI guidelines. Data were statistically analyzed to assess prevalenceand resistance associations. Out of 365 isolates, 34 (9.32%) yielded Pseudomonas aeruginosa, with urine as the most common source. Isolates were more frequent in medical wards, thoughnosignificant age-related differences were noted. Resistance was extremely high: 100%to cefepime, 97.1% to cefotaxime, and 85.3% to ciprofloxacin, while ofloxacin (50%) and meropenem(52.9%) showed comparatively lower resistance. In conclusion, Pseudomonas aeruginosaisolates from UBTH exhibited high MDR levels, limiting therapeutic options. Routinesurveillance, antimicrobial stewardship, and infection control measures are essential tocurbresistance, while novel therapies such as phage treatment and β-lactam/β-lactamase inhibitorcombinations may offer future solutions