Vancomycin

Vancomycin-resistant staphylococcus aureus (VRSA) is a strain of S. aureus that has developed overtime due to the overuse ofvancomycin as an antibiotic for the treatment against S.aureus xinfections which have reduced the available options of managing the pathogen that causes a lot of infections including UTIs. The aim of this study is to determine the prevalence of Vancomycin-Resistant Staphylococcus aureus (VRSA) from urine samples of selected students in the University of Benin, Edo State. A cross-sectional descriptive design was used, and sixty urine samples were collected and analyzed using standard microbiological andbiochemical methods to isolate and identify vancomycin-resistant S.aureus(VRSA) and assess their antibiotic susceptibility patterns. The results revealed that 23.3% of samples showed leukocytes, while Staphylococcus aureus (33%) was the most predominant isolate, followed by Escherichia coli (21%) and Pseudomonas spp. (11%). The overall VRSA prevalence was 6.7%, with a higher rate among females (5.0%) than males (1.7%). The isolates exhibited high resistance to β-lactam antibiotics, while most remained susceptible to ofloxacin and ceftriaxone. The findings emphasize a significant occurrence of antimicrobial resistance particularly vancomycin-resistant S. aureus, among university students. It concludes that improved hygiene practices, rational antimicrobial use, and continuous antimicrobial surveillance are vital to controlling the spread of resistant strains in the university communities.