THE EFFECT OF RELATIVE HUMIDITY ON THE DISSOLUTION PROFILES OF CERTAIN BRANDS OF ASPIRIN TABLETS IN THE NIGERIAN MARKET
Faculty
Year of Publication
Keyword
upload
Publication Type
Abstract
Ensuring that medications are effective is crucial for the pharmaceutical industry. Factors like humidity can have undesirable impact on the Dissolution Profiles of these drugs, which could affect their therapeutic efficacy. This study explores the frequently disregarded connection between humidity and the Dissolution Profiles of aspirin tablet for five popular brands in the
Nigerian market. It is essential to understand this relationship to guarantee both patient safety and standard drug performance. Aim and objectives: the aim of this study was to investigate how varying relative humidity affects the dissolution profiles of the various brands aspirin tablets after prolonged storage under these conditions. Methods: The dissolution profiles of five well-known brands of aspirin tablets available in Nigeria were investigated using standard pharmacopeial methods. Two humidity levels, 0% and 70%, were used for the dissolution studies to replicate typical Nigerian ambient conditions. Dissolution Profiles were produced, and the rates and extents of dissolution under various humidity levels were compared. Results : the results from the experiment showed that Elevated relative humidity seems to quicken the process of dissolution for the five brands of aspirin used in the study which could result in quicker drug release and absorption. On the other hand, reduced humidity can hinder drug disintegration and cause a delayed release of the medication. Conclusion : This study confirmed that changes in the dissolution profiles occur when Aspirin tablets are stored under varying relative humidity conditions of 0% Relative humidity and 70%Relative humidity. This study revealed that there is an undesired reduction in the percentage of the drug released when stored at 0% relative humidity and also an undesired increase in the percentage of drug released when stored at 70% relative humidity as seen from the results over the 10 week period. It is imperative that patients, caregivers and even manufacturers are educated on the need to store tablets in facilities and areas of optimum relative humidity in order to preserve the efficacy of these drugs.
Nigerian market. It is essential to understand this relationship to guarantee both patient safety and standard drug performance. Aim and objectives: the aim of this study was to investigate how varying relative humidity affects the dissolution profiles of the various brands aspirin tablets after prolonged storage under these conditions. Methods: The dissolution profiles of five well-known brands of aspirin tablets available in Nigeria were investigated using standard pharmacopeial methods. Two humidity levels, 0% and 70%, were used for the dissolution studies to replicate typical Nigerian ambient conditions. Dissolution Profiles were produced, and the rates and extents of dissolution under various humidity levels were compared. Results : the results from the experiment showed that Elevated relative humidity seems to quicken the process of dissolution for the five brands of aspirin used in the study which could result in quicker drug release and absorption. On the other hand, reduced humidity can hinder drug disintegration and cause a delayed release of the medication. Conclusion : This study confirmed that changes in the dissolution profiles occur when Aspirin tablets are stored under varying relative humidity conditions of 0% Relative humidity and 70%Relative humidity. This study revealed that there is an undesired reduction in the percentage of the drug released when stored at 0% relative humidity and also an undesired increase in the percentage of drug released when stored at 70% relative humidity as seen from the results over the 10 week period. It is imperative that patients, caregivers and even manufacturers are educated on the need to store tablets in facilities and areas of optimum relative humidity in order to preserve the efficacy of these drugs.
Supervisor(s)
co-supervisor