PREPARATION AND CHARACTERIZATION OF A CO- PROCESSED EXCIPIENT FOR FAST TABLET DISINTEGRATION
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Abstract
Introduction: Excipients play a crucial role in pharmaceutical tablet formulation, influencing drug stability,bioavailabilty,and mechanical properties.Traditional excipients often present challenges such as poor flowability,inadequate compressibility and inconsistent drug release to address these limitations,co-processed excipients,which combine multiple excipients to enhance functionality,have gained attention.
Purpose: The primary aim of this study is to prepare and characterize a co-processed excipient for direct compression and fast tablet disintegration.
Method: The novel excipient was prepared through milling and co-processing of the selected excipient.The excipients physical and flow properties were characterized by measuring bulk density, tapped density,car’s index, hausner’s ratio, moisture content, swelling index and hydration capacity.Paracetamol tablets were formulated using the excipient in different concentrations an evaluated for weight uniformity,hardness,friability,disintegration time and dissolution rate.
Results: The co-processed excipient exhibited improved physiochemical properties with hardness(6.6-7),Disintegration time(1.45secs) and drug release profile of above 80% within 50mins in two separate batches.It showed poor flow properties with carr’s index of 60% and hydration capacity of 1.18
Conclusion: The result from the disintegration time of the different batches of tablet
formulation with the co-processed excipient showed signs of a fast disintergratig tablet with a disintegration time of 1.45secs.
Purpose: The primary aim of this study is to prepare and characterize a co-processed excipient for direct compression and fast tablet disintegration.
Method: The novel excipient was prepared through milling and co-processing of the selected excipient.The excipients physical and flow properties were characterized by measuring bulk density, tapped density,car’s index, hausner’s ratio, moisture content, swelling index and hydration capacity.Paracetamol tablets were formulated using the excipient in different concentrations an evaluated for weight uniformity,hardness,friability,disintegration time and dissolution rate.
Results: The co-processed excipient exhibited improved physiochemical properties with hardness(6.6-7),Disintegration time(1.45secs) and drug release profile of above 80% within 50mins in two separate batches.It showed poor flow properties with carr’s index of 60% and hydration capacity of 1.18
Conclusion: The result from the disintegration time of the different batches of tablet
formulation with the co-processed excipient showed signs of a fast disintergratig tablet with a disintegration time of 1.45secs.
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