E. Osazuwa

Recycling fruit peel trash has not only helped to reduce solid waste concerns, but it has also assisted in the discovery of key compounds that have been found to have significant uses. Fruit peel wastes may contain useful components similar to those found in fruit. These beneficial compounds can be employed to create pharmaceutical/medicinal, nutritional, and energy-rich formulations. The study seek to evaluate of Avocado peel extract as a potential agent for ameliorating cardiotoxicity induced by lead and cadmium. The fresh avocado fruits were obtained from a local market (Oba market Oredo) Local Government of Edo state. The seed was extracted, cleaned and prepared. The following test was carried out lipid profile and antioxidant and lipid peroxidation. The level of heavy metal present in the heart showed least in lead and cadmium concentration in group four and five compared the other groups. In the administration of the extract showed increase in uric acid, HDL, LDL, direct bilirubin and total bilirubin in the heart on male albino rat when compared to control. From the result, the administration of the extract showed decrease in triglyceride level in all doses when compared to control except for the avocado peel extract with a 100 mg/ml showed increase when compared to control. From the result, the administration of the extract showed increase at significant (p < 0.05) in Creatinine and Albumin level on male albino rat when compared to control. The administration of the extract showed increase at significant (p < 0.05) in MDA, SOD and CAT level in the heart on male albino rat when compared to control. The administration of the avocado peel extract with doses of 75 mg/ml and 100 mg/ml showed significant decrease in MDA, SOD levels in the blood on male albino rat when compared to control and also, the avocado extract at dosage of 75 mg/ml showed significant increase in CAT levels in the blood on male albino rat when compared to control. While at dosage of 100 mg/ml showed decrease at significant (p < 0.05) in CAT levels in the blood on male albino rat when compared to control. The avocado peel extract showed significant decrease in MDA in the testes on male albino rat when compared to control. The ethanol avocado peel extract showed significant increase in, SOD, and CAT levels in the testes on male albino rat. The protective effect of avocado peel against cadmium and lead toxicity, owing to its polyphenol and flavonoid content represents a potential avenue for treating heavy metal-related health conditions.