Hepatotoxicity screening

This study evaluated liver function of diabetic rat treated with ethanol extract of Chrysophyllum albidum stem back. Diabetes was induced intraperitoneally in the rat with streptozotocin [STZ, 40mg/kg body weight (bwt)], and rats with fasting blood glucose levels exceeding 200 mg/dL were considered diabetic. Animals were treated with 200 mg/kg bwt ethanol extract of C. albidum stem bark or 50 mg/kg bwt metformin for 14 days, with a diabetic control group receiving no treatment. Fasting blood glucose levels were monitored using an Accu-check glucometer before and during treatment. Blood sample collected after euthenization were used for biochemical analysis. Results showed a significant reduction in blood glucose level in metformin group compared to Ethanol extract of C.albidum (p < 0.05). Activities of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) in the plasma shown no significant increase when compared to control (p>0.05). Similarly, Albumin and Bilirubin concentration show no significant increase (p>0.05). These findings suggest that ethanol extract of C. albidum stem bark particularly at 200 mg/kg bwt, exerts significant ethnomedicinal effect on diabetic rat liver.