EFFECTS OF MELATONIN

Alcohol (ethanol) is a widely consumed psychoactive substance known to induce oxidative stress and gastrointestinal mucosal damage, particularly in the stomach. Chronic alcohol exposure generates reactive oxygen species (ROS) and disrupts mucosal integrity. M melatonin on alcohol-induced gastric toxicity in adult male Wistar rats. Forty adult male Wistar rats (150–180 g) were randomly divided into four groups (n=10): control, melatonin only (5 mg/kg), alcohol only and melatonin plus alcohol. All treatments were administered orally via gavage for 28 days. After the exposure period, a weight test was done, and gastric tissues were harvested for histopathological analysis. Statistical analysis was performed using one-way ANOVA with significance set at p<0.05. Alcohol induced ulceration in the mucosa of the stomach, and the ulcer induced was irregularly -shaped. The control group showed a normal gastric architecture, while the group given alcohol only exhibited disruption of the muscularis mucosa with the formation of a irregular-shaped ulcer. The group given alcohol and melatonin showed that melatonin attenuated the ulcerative lesion in the stomach, indicating that melatonin effectively resolved alcohol-induced gastric injury.