AKPOROBO EJEGUO

This study comprehensively examines the phytochemical composition and physiological effects of Glycine Max extract on Wistar rats, shedding light on its potential therapeutic applications. Through qualitative analysis, the extract was found to contain a diverse array of phytochemicals, including reducing sugars, saponins, flavonoids, phenolics, eugenols, terpenoids, alkaloids, and proteins. Three (3) groups (A-C) of six (6) each were created from the eighteen (18) juvenile Wistar rats (PND 42) that ranged in weight from 35g to 69.5g and were the offspring of DAMS. Group A served as the reference point (control) while B and C were the therapy groups, 250 mg/kg and 500 mg/kg of Glycine max aqueous extract, respectively, were administered to them as treatment. With the aid of an orogastric tube, the DAMS was fed orally for the duration of its four-week treatment. At the conclusion of six (6) weeks, the juveniles were fed, weighed, and slaughtered. Detailed physiological assessments, including animal weights and organ weights, were conducted, revealing dose-dependent changes in body mass and
relative organ weights. Histological analysis of tissue samples provided insights into the extract's impact on tissue morphology and integrity. Furthermore, antioxidant activity was evaluated through assays measuring catalase, superoxide dismutase, glutathione peroxidase, and malondialdehyde levels, indicating the extract's potential to modulate oxidative stress pathways. The findings underscore the multifaceted biochemical and physiological effects of Glycine Max extract, suggesting its promising role as a therapeutic agent. Further investigation is warranted to elucidate its mechanisms of action and explore its clinical applications in treating various pathological conditions.

Soybean is an annual herbaceous legume plant that has diverse applications, serving as animal feed, fodder, and human food and beverage, including flour, starch, oil, spices, and culinary herbs. Soybean have been reported to have a variety of pharmacological properties including hepatoprotective activity. It’s effect on the fetus is rather relatively unknown. Thus, this study aimed to investigate the effect of soybean (Glycine max) on the histology of fetal liver in Wistar rats. Eighteen (18) adult juvenile Wistar rats with an average weight of 60 g were randomly assigned into three (3) groups (A-C). Group A served as control; Group B was administered 250 mg/Kg body weight of Glycine max; Group C was administered 250 mg/Kg body weight of Glycine max.The administration lasted for 21 days and was done orally using an orogastric tube. After the duration of administration, the animals were weighed, anaesthetized and sacrificed, with the liver processed for routine hematoxylin and eosin staining for histological
evaluation. From this study, results showed a significant decrease (p<0.05) in body weight change in the groups administered Glycine max when compared to control. There was also a significant decrease (p<0.05) in fetal weight and Crown-rump length in the group given 500mg/Kg body weight of Glycine max when compared to control. Histological findings showed relatively normal liver architecture in the groups given Glycine max when compared to control as evidenced by developing hepatocytes radiating from central vein, and sinusoids. In conclusion, findings from this study suggest that Soybean resulted in significant alterations in maternal and fetal health outcomes (especially at 500 mg/Kg body weight dosage). However, the observed effects may be primarily physiological as there were histological alterations.

Soybean is an annual herbaceous legume plant that has diverse applications, serving as animal feed, fodder, and human food and beverage, including flour, starch, oil, spices, and culinary herbs. Soybean have been reported to have a variety of pharmacological properties including hepatoprotective activity. It’s effect on the fetus is rather relatively unknown. Thus, this study aimed to investigate the effect of soybean (Glycine max) on the histology of fetal liver in Wistar rats. Eighteen (18) adult juvenile Wistar rats with an average weight of 60 g were randomly assigned into three (3) groups (A-C). Group A served as control; Group B was administered 250 mg/Kg body weight of Glycine max; Group C was administered 250 mg/Kg body weight of Glycine max.The administration lasted for 21 days and was done orally using an orogastric tube. After the duration of administration, the animals were weighed, anaesthetized and sacrificed, with the liver processed for routine hematoxylin and eosin staining for histological evaluation. From this study, results showed a significant decrease (p<0.05) in body weight change in the groups administered lycine max when compared to control. There was also a significant decrease (p<0.05) in fetal weight and Crown-rump length in the group given 500mg/Kg body weight of Glycine max when compared to control. Histological findings showed relatively normal liver architecture in the groups given Glycine max when compared to control as evidenced by developing hepatocytes radiating from central vein, and sinusoids. In conclusion, findings from this study suggest that Soybean resulted in significant alterations in maternal and fetal health outcomes (especially at 500 mg/Kg body weight dosage). However, the observed effects may be primarily physiological as there were histological alterations.