GLYCINE ON CADMIUMINDUCED, GASTRIC DAMAGE IN ADULT, WISTAR RATS

A crucible furnace is an equipment used in the foundry workshop or industry for melting metals for casting operations. They are the oldest type of melting furnaces used for melting and holding small batches of non-ferrous alloys for which a refractory crucible filled with metal is heated through the crucible wall. This paper focuses on the development of a 38-kilogram capacity LPG butane gas-fired crucible furnace used to melt aluminium metal. Drawings were produced to aid the fabrication of the furnace using a mild steel sheet while the other components needed for the fabrication were selected based on functionality, durability, availability of local materials and cost. The test was carried out on the furnace to evaluate the performance and the results obtained showed that it took the furnace 24minutes to completely melt 38kg of aluminum scrap between 630 0C to 700 0C. The heating rate is 56.110 C/min, melting rate of 1.58kg/min and a 39.6% maximum efficiency, which is quite impressive when compared with the conventional crucible furnace.

An Experimental Study in Adult Wistar Rats Metal poisoning and its impact on human health have increased due to industrialization and anthropogenic activities. This study aims to investigate the effect of glycine on cadmium-induced gastric damage in adult Wistar rats. Thirty rats were divided into six groups, including control, cadmium only, glycine only, and combinations of cadmium and glycine. Various biochemical markers were assessed, including oxidative stress indicators (SOD, MDA, CAT) and total protein. Histological analyses were performed on stomach tissues. Cadmium administration led to reduced body weight and
increased malondialdehyde (MDA) levels, indicating oxidative damage. Superoxide dismutase (SOD) activity decreased, revealing compromised antioxidant defenses. However, catalase activity was largely unaffected by cadmium. Interestingly, glycine administration showed positive effects. It attenuated cadmium-induced MDA increase, maintained glutathione levels, and improved SOD activity. It also increased total protein levels. Histological observations demonstrated that cadmium induced inflammatory responses, muscle degeneration, and congestion in the stomach. Glycine treatment mitigated these effects, leading to near-normal
tissue architecture. This study demonstrates that cadmium exposure can lead to oxidative stress and cellular damage, while glycine supplementation can exert a gastro-ameliorative effect by enhancing antioxidant defenses, maintaining glutathione levels, and mitigating histological alterations. These findings offer insight into the potential therapeutic benefits of glycine against cadmium-induced gastric damage. Glycine's availability and safety make it a promising avenue for further research and development of affordable gastro-ameliorative interventions