INFLUENCE OF ACALYPHA WILKISENIA ON MALONDIALDEHYDE AND GLUTATHIONE PEROXIDASE, IN1,2-DIMETHYLHYDRAZINE INDUCED COLON TUMORS IN WISTAR RATS

This research examines the effect of ethanol leaf extract of Acalypha wilkisenia on malondialdehyde (MDA) and glutathione peroxidase (GPx) levels in wistar rats with 1,2 dimethylhydrazine(DMH) induced colon tumors. Colon cancer is a leading cause of cancer related mortality ,is often characterized by elevated oxidative stress markers such as MDA and altered antioxidant enzyme activities, including GPx. Alcalypha wilkisenia, a plant commonly known for its antioxidant properties, was evaluated for its potential therapeutic effects. Wistar rats were divided into six groups: Control, DMH treated only, Xeloda, DMH plus ethanol leaf extract of Alcalypha wilkisenia . Over the experimental period, MDA and GPx levels were measured using standard biochemical assays. Results indicated that DMH significantly increased MDAlevels and decreased GPx activity, indicative of oxidative stress and impaired antioxidant defense. Conversely administration of Acalypha wilkisenia extract to DMH treated rats resulted in a significant reduction in MDA levels and restoration of GPx activity , suggesting a protective effect against colon carcinogenesis through the modulation of oxidative stress markers, highlighting its potential as a complementary therapeutic agent in colon cancer management .Further studies are needed to elucidate the underlying mechanisms and confirm these effects in clinical settings