WISTAR RATS

Kigelia africana, commonly known as the sausage tree, is a plant widely recognized for its medicinal properties in various traditional medicine systems across Africa. The aim of this study was to determine the effect of total flavonoid Rich Extract (FRE) on membrane stabilization and the hematological property of the rat. The study was carried out in Wister rats exposed to Carrageenan for 24 hours. The membrane stabilizing effect of the Flavonoid Rich Extract was evaluated using the Human Red Blood Cell (HRBC) membrane stabilizing method. The Flavonoids Rich Extract fraction in heated induced hemolysis and hypotonic solution of HRBC as against the standard (aspirin) in wastar rats. The total Flavonoids Rich Extract has shown protection against hemolysis of human red blood cells either through heatinduced or hypertonicity, that is it can be used for the management of in-vitro inflammation. The in vitro anti-inflammatory activity of the total flavonoids extract from the plant Kigelia africana was assessed using the in vivo hypoglycemic (anticancer) and antineoplastic (antitumor) activities of the extracts. The results showed a significant decrease (p > 0.05) in the White Blood Cells (WBC) of carrageenans only treated rat, carrageeenans and sodium diclofenac treated rats, and a significantly increase in it WBC of rats treated with Carrageenenan and Quercetin, Carrageenans and Flavonoids Rich Extract (100 mg/kg body wt.), and Carrageenans and Flavonoids Rich Extract (200 mg/kg body wt.), when compared to the control group