CHOLESTEROL

The liver plays a crucial role in metabolism and detoxification, making it highly susceptible to oxidative stress. This study dives into the effect of a boiled egg yolk-formulated diet on the antioxidant status and histological integrity of the liver of female Wistar rats. A total of 16 female Wistar rats were randomly assigned to four groups: group one( which was fed with boiled egg). group 2 (which was fed with synthetic cholesterol), group 3(which serve as positive control group) and group 4 (which serves as negative control group) for six weeks. After six weeks of feeding, the rats were sacrificed and the liver were taken for examination/analysis. After this was done, the various antioxidants enzymes were examined such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), along side with malondialdehyde (MDA) which serves as a marker of oxidative stress. The Liver tissues were also examined histologically to assess structural changes. The results showed a significant increase in antioxidant enzyme activities in the boiled egg yolk-fed group compared to the positive control group, suggesting enhanced antioxidant defense mechanisms. In addition,MDA levels were reduced, stating decreased lipid peroxidation and oxidative stress. The histological analysis revealed better-preserved liver architecture in the boiled egg yolk group, with minimal inflammatory changes compared to the cholesterol-rich diet group, which showcased signs of cellular degeneration. In conclusion, the consumption of a boiled egg yolk- formulated diet may contribute to improved liver antioxidant status and histological integrity. These findings highlight the nutritional benefits of egg yolk and its potential role in maintaining liver health.