Dissolution studies

Purpose: This study aimed to investigate the interaction between Beta Cleanser Bitters and two antibiotics, ciprofloxacin and amoxicillin. Method: Commercial brands of Ciprofloxacin, amoxicillin and Beta Cleanser Bitters were purchased and evaluated for the physiochemical properties. The interaction between the antibiotics and Beta Cleanser Bitters were evaluated using the disintegration time test and dissolution studies. Further interactions studies were carried out using absorbance inference studies and FTIR studies. Results: The presence of Beta Cleanser Bitters showed no contrasting effects on the disintegration times of the two drugs. For ciprofloxacin in the presence of Beta Cleanser Bitters, the dissolution drug release remained relatively stable and no significant difference while for amoxicillin there was a decrease in drug release in the presence of the bitters. FTIR analysis revealed similarity in spectra, suggesting minimal chemical interactions between amoxicillin and Beta Cleanser Bitters and for Ciprofloxacin, revealed difference in spectra, indicating an interaction. Conclusion: The study suggests that Beta Cleanser Bitters may exert some influence on the dissolution and disintegration behavior of ciprofloxacin and amoxicillin, though chemical interactions appear to be limited