PHILIP OGOCHUKWU NWEKE

Variable drug release from solid dosage forms has been a major cause of bioavailability problems. The two main processes by which they release drugs are disintegration and dissolution. The objective of the present study was to assess the disintegration and dissolution of Omeprazole in different beverages like Coca-Cola, Chivita juice, Hollandia yoghurt and Malta Guinness. The test was carried out per the US Pharmacopoeia standard for delayedrelease drugs. A hybrid medium of different beverages and pH 6.8 phosphate buffer (250ml) was prepared to mimic in-vivo conditions. The result showed that the disintegration time increased in Hollandia yoghurt, while it decreased in Coca-Cola, Malta Guinness and Chivita juice. As the viscosity of fluid increases, the disintegration time was also increased. Coco- cola which contains Carbon Dioxide is implicated in reducing the disintegration time of omeprazole. Since the dissolution profile phase of the study, the results reflected that the drug release was retarded in Hollandia yoghurt and it was sufficiently released in Coca-Cola, Malta Guinness and Chivita juice. From the above study, it can be concluded that there is variation in the disintegration time and dissolution profile of the studied drug in different beverages. Hollandia yoghurt had poor disintegration and dissolution quality compared to other dissolution media used.