Oghene-Oruese Celine AVWENAYERI

Medicinal plants are reliable and effective in treating various health issues, ranging from minor to major health issues. This study examined the effect of Acanthus montanus leaf aqueous extract on the lipid profile of male Wistar Rats. Various standard methods were used to determine the effect of the aqueous extract of A. montanus leaf on lipid levels. The aqueous extract of the plant was administered orally at different dosages of 25, 50, and 100 mg/kg to the animals. The 100 mg/kg of Sildenafil Citrate was the positive control, while 1ml of distilled water was administered as the negative control. Treatments were administered for 14 days. The results obtained from this experiment showed that the plant extract can slightly reduce cholesterol levels (130-140 mg/dl), triglyceride levels (52-96 mg/dl), high-density (39.5-44.5 mg/dl) and low-density lipoprotein (77-88 mg/dl), and balance testosterone levels (3.15-3.70 mg/ml). This research supports the potential use of the extract as a therapeutic or preventive agent for hypertriglyceridemia while preserving lipoprotein balance and reproductive hormone homeostasis.