HYPOGLYCEMIC EFFECTS OF BITTER KOLA Garcinia kola ON ALBINO RATS

Maintaining steady blood glucose levels is essential for metabolic balance and overall health. This study explores the potential of bitter kola, a rich source of bioactive compounds, to regulate blood sugar levels. Despite the global prevalence of diabetes mellitus, research on the acute and sub-acute impacts of bitter kola on blood glucose levels remains limited. The research utilizes various approaches, including testing for acute toxicity, evaluating normal blood sugar levels, and conducting anti-diabetic experiments on rats. It found that administering ethanol extracts of bitter kola at doses up to 5000 mg/kg is safe and can lower blood glucose levels in both normal and diabetic rats, indicating its potential in managing hyperglycemia and diabetes mellitus, comparable to the standard drug Glibenclamide. Moreover, the extract illustrated possible liver protection abilities and showed a positive influence on lipid levels, notably lowering cholesterol, triglycerides, and LDL levels. Crucially, it didn't negatively affect kidney tissue, indicating its safety. These results emphasize the potential of bitter kola as a natural dietary approach in managing diabetes, providing optimism for better blood sugar control and overall health.