VISUAL INSPECTION, DISSOLUTION TEST AND SPECTROPHOTOMETRIC EVALUATION OF SOME BRANDS OF TETRACYCLINE AVAILABLE IN PHARMACIES IN BENIN CITY
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Abstract
Background: .The tetracycline class of antimicrobials demonstrates a broad spectrum of activity against various pathogens, encompassing Gram-positive and Gram-negative bacteria, as well as atypical organisms.However, their use for bacterial infections has been restricted in recent years due to the emergence of resistant organisms employing efflux and ribosomal protection mechanisms.However tetracycline has been used for therapeutic reasons in both humans and animals
Aim: The primary aim is to perform a quantitative and qualitative analysis on various brands of tetracycline found in pharmacies in Benin city. Method: Visual inspection was performed according to World health Organisation Visual Inspection of Medicines Template while the dissolution test was performed using the United State Pharmacopoeia modified method of spectrometry according to Ahmed et al was used and absorbance was taken at 362nm.
Results: The visual inspection showed that 90% of the brand inspected met the required standard according to the USP. The dissolution test showed that the percentage content in 20 40 and 60 minutes was within the range of 91.31 - 99.53, 92.62 - 99.53 and 97.83 - 99.57 respectively the spectrometry test shows that all the brands met up to the 90 -125% (USP).
Conclusion: The conclusion of this research shows that the analysed tetracycline brands follow the official monographs, except for the color deviation that was noted in the T7 tablets.
Aim: The primary aim is to perform a quantitative and qualitative analysis on various brands of tetracycline found in pharmacies in Benin city. Method: Visual inspection was performed according to World health Organisation Visual Inspection of Medicines Template while the dissolution test was performed using the United State Pharmacopoeia modified method of spectrometry according to Ahmed et al was used and absorbance was taken at 362nm.
Results: The visual inspection showed that 90% of the brand inspected met the required standard according to the USP. The dissolution test showed that the percentage content in 20 40 and 60 minutes was within the range of 91.31 - 99.53, 92.62 - 99.53 and 97.83 - 99.57 respectively the spectrometry test shows that all the brands met up to the 90 -125% (USP).
Conclusion: The conclusion of this research shows that the analysed tetracycline brands follow the official monographs, except for the color deviation that was noted in the T7 tablets.
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