PRELIMINARY ANALYSIS IN TO THE FORMULATION OF PROMPT DISINTEGRATINGCIPROFLOXACINTABLETSUSINGPECTIN EXTRACTED FROM CITRUS SINENSIS PEEL AS A DISINTEGRANT
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Abstract
Introduction: Disintegrating agents are used to speed up the breakdown of solid dosage forms, such as tablets and capsules, after administration. Pectin is a complex polysaccharide composed of galacturonic acid units commonly used in the pharmaceutical industry as a disintegrant due to its ability to absorb water and swell leading to the disruption of tablet structure and promoting
rapid disintegration.
Objective: To investigate the feasibility of incorporating pectin obtained from citrus sinensis peel as a fast acting disintegrant and assessing its impact on tablet disintegration and dissolution profile and to compare the performance of the locally obtained pectin based-formulations with
other disintegrants.
Method: Pectin was extracted using the hot acid extraction method and various batches of ciprofloxacin tablets (F1-F7) were prepared by wet granulation technique. The granules
produced were subjected to pre-compression (bulk and tapped densities, angle of repose, Hausner’s ratio and Carr’s index) and post compression (hardness, friability, weight uniformity and dissolution) evaluations respectively.
Results: The granular mixtures of the various batches had angle of repose between 22.53° to 28.60° indicating excellent flow. The Hausner’s ratio ranged from 1.12 to 1.22 while the Carr’s index was between 11.69% and 17.20%. The bulk and tapped densities were found to be between 0.41gm/cm3 to 0.58gm/cm3 and 0.42gm/cm3 to 0.60gm/cm3 respectively. The seven batches had uniform weight with low standard deviation values of less than ±5% which are within the
B.P limits. The hardness values ranged from 7.2 to 10.0 kg/cm2 while the friability values of 0.60- 0.98% were found to be less than 1%. The disintegration time of the pectin formulation F2-F6 ranged from 11.5-26.4min as compared with those of the standards F1 and F7 whose disintegration time value were 8.2 and 13.5 respectively. The in vitro dissolution result showed that F6 had the best dissolution profile among the formulations containing pectin.
Conclusion: Pectin obtained from Citrus sinensis at a concentration of 15% showed excellent disintegrating property when compared with sodium starch glycolate and maize starch which are super disintegrants and conventional disintegrants respectively.
rapid disintegration.
Objective: To investigate the feasibility of incorporating pectin obtained from citrus sinensis peel as a fast acting disintegrant and assessing its impact on tablet disintegration and dissolution profile and to compare the performance of the locally obtained pectin based-formulations with
other disintegrants.
Method: Pectin was extracted using the hot acid extraction method and various batches of ciprofloxacin tablets (F1-F7) were prepared by wet granulation technique. The granules
produced were subjected to pre-compression (bulk and tapped densities, angle of repose, Hausner’s ratio and Carr’s index) and post compression (hardness, friability, weight uniformity and dissolution) evaluations respectively.
Results: The granular mixtures of the various batches had angle of repose between 22.53° to 28.60° indicating excellent flow. The Hausner’s ratio ranged from 1.12 to 1.22 while the Carr’s index was between 11.69% and 17.20%. The bulk and tapped densities were found to be between 0.41gm/cm3 to 0.58gm/cm3 and 0.42gm/cm3 to 0.60gm/cm3 respectively. The seven batches had uniform weight with low standard deviation values of less than ±5% which are within the
B.P limits. The hardness values ranged from 7.2 to 10.0 kg/cm2 while the friability values of 0.60- 0.98% were found to be less than 1%. The disintegration time of the pectin formulation F2-F6 ranged from 11.5-26.4min as compared with those of the standards F1 and F7 whose disintegration time value were 8.2 and 13.5 respectively. The in vitro dissolution result showed that F6 had the best dissolution profile among the formulations containing pectin.
Conclusion: Pectin obtained from Citrus sinensis at a concentration of 15% showed excellent disintegrating property when compared with sodium starch glycolate and maize starch which are super disintegrants and conventional disintegrants respectively.
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