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Abstract
Nature has long been a source of medicine, with traditional plant-based remedies playing a key role in modern healthcare. About 80% of the global population relies on traditional medicine. A polyherbal remedy from plant leaves including; Moringa oleifera, Anacardium occidentale, Carica papaya, Azadirachta indica, Mangifera indica, Cymbopogon citratus, Justicia carnea, Ocimum gratissimum and Psidium guajava is gaining popularity for their use in the treatment
of various ailments including malaria. Although many phytochemicals present in these plants have beneficial effects, studies however need to be carried out to verify their safety and efficacy. This study aims to evaluate the safety potential of the polyherbal remedy on male Wistar rats. Fifty (50) grams of each plant were weighed and chopped into smaller pieces and placed in a pot. Three (3L) liters of water was added and boiled for 30 minutes. This procedure was repeated for multiple extraction. After boiling, the extracts were cooled, filtered and the filtrates evaporated to dryness in porcelain dishes, over a boiling water bath. HPLC analysis was performed using a uBondapak C18 column and a UV 254nm detector. The effect of the extract on biochemical parameters was determined following a 14-day daily administration of the extract via the oral route, on male Wistar rats.
of various ailments including malaria. Although many phytochemicals present in these plants have beneficial effects, studies however need to be carried out to verify their safety and efficacy. This study aims to evaluate the safety potential of the polyherbal remedy on male Wistar rats. Fifty (50) grams of each plant were weighed and chopped into smaller pieces and placed in a pot. Three (3L) liters of water was added and boiled for 30 minutes. This procedure was repeated for multiple extraction. After boiling, the extracts were cooled, filtered and the filtrates evaporated to dryness in porcelain dishes, over a boiling water bath. HPLC analysis was performed using a uBondapak C18 column and a UV 254nm detector. The effect of the extract on biochemical parameters was determined following a 14-day daily administration of the extract via the oral route, on male Wistar rats.
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