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Abstract
The increasing global reliance on medicinal plants for therapeutic purposes especially in developing countries has intensified the need for scientific validation of their biochemical activities and safety. Terminalia mantaly H. Perrier, a member of the Combretaceae family is traditionally used in various African communities for the treatment of wounds, gastrointestinal issues, and inflammatory conditions. This study investigated the effects of the methanol leaf extract of T. mantaly on various biochemical parameters of female Wistar rats, when administered for 28 days. Fresh leaves of T. mantaly were harvested, authenticated, shade-dried and then oven-dried, before milling into powdered form using an electric miller. The resulting powdered leaf was subjected to methanol (100%) extraction with the aid of a Soxhlet apparatus, concentrated with a rotary evaporator, and reduced to dryness on a thermostatically controlled water bath (65℃). The extract was administered orally to four groups of female Wistar rats containing 5 rats each, at concentrations of 200, 400 and 800 mg/kg respectively, for 28 days. The liver, renal and lipid parameters were assayed using standard methods
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