Etinosa Godspower AGHAHOWA

Haemolytic anaemia is characterised by accelerated erythrocyte destruction and is often accompanied by oxidative damage and organ dysfunction. Medicinal plants used in traditional medicine may offer protective and regenerative benefits in anaemic conditions. This study evaluated the regenerative effects of a polyherbal aqueous leaf extract of Ipomoea batatas, Justicia carnea and Ficus sur on selected organs in phenylhydrazine-induced haemolytic anaemic rats. Anaemia was induced in Wistar rats using phenylhydrazine hydrochloride. Animals were treated with graded doses of the polyherbal extract, while control groups included normal and anaemia-induced untreated rats. Liver, spleen and thymus tissues were harvested and processed for histopathological examination using haematoxylin and eosin staining. Phenylhydrazine-induced anaemia caused marked histopathological alterations in the liver, spleen and thymus, including hepatocellular degeneration, splenic architectural distortion and thymic involution. Treatment with the polyherbal extract resulted in varying degrees of tissue protection and structural recovery across the organs examined. The polyherbal aqueous extract of I. batatas, J. carnea and F. sur demonstrated protective and regenerative effects against phenylhydrazine-induced organ damage, supporting its potential role in the management of haemolytic anaemia.