BLESSING EJENAKEWE

QUANTITATIVE ANALYSIS OF HYDROQUINONE IN SKIN- LIGHTENING CREAMS: DETECTION, REGULATORY COMPLIANCE, AND POTENTIAL HEALTH RISKS

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Abstract
This study analyzed the concentrations of hydroquinone in various skin-lightening creams obtained from Ring Road, Benin City, Edo State, Nigeria. Ten cream samples were purchased locally, and hydroquinone levels were determined using UV spectrophotometry at a wavelength of 302 nm. A seven-point calibration curve was prepared to quantify the hydroquinone content in each sample. The results showed that hydroquinone concentrations ranged from 0.0030% to 0.0466%, with Caroline cream containing the highest concentration (0.0466%), while Cussons Baby cream had the lowest (0.0030%). When compared with regulatory standards set by NAFDAC, FDA, and EMA, all detected hydroquinone concentrations were found to be below the permissible limit of 2%. However, the presence of hydroquinone in these products, even at low levels, raises concerns about potential long-term exposure risks, especially for individuals who frequently use multiple skin-lightening products. To mitigate these risks, this study recommends stricter regulatory enforcement, clearer product labeling, standardized formulations, and increased public awareness regarding the effects of hydroquinone. Further research should focus on evaluating cumulative exposure risks and identifying safer alternatives for skin-lightening formulations.
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