BIOCHEMISTRY

Asthma is an inflammatory disease of the lungs that causes oxidative stress (Almohawes and
Alruhaimi, 2019). Asthma is characterized by airway inflammation, oxidative stress and
increased Malondialdehyde level. It doesn’t have a cure cannot be treated but it was discovered
that a plamt known as adansonia digitata commonly referred to as African Baobab. The leaves
of this tree serve as a primary source of food and traditional medicine for numerous African
populations, and they are consumed either fresh or in a dried form (Besco et al., 2007). The plant
have effects on asthma due to its renowned for its pharmacological properties including antiinflammatory and anti-oxidant properties. This study aims at providing valuable insights into the
therapeutic potential of adansonia digitata in managing asthma by its modulation of
Malondialdehyde levels and contribute to supporting the use of natural products for management
of asthma.

Malaria caused by Plasmodium falciparum is still a global challenge to date. The major process for malaria parasite survival within red blood cells is the detoxification of heme, a toxic byproduct released from hemoglobin digestion, into a crystalline pigment called hemozoin. Agents which inhibit this process can be used to curb the parasitic development. The discovery of such agents can be done using the β-hematin inhibition assay, in-vitro studies using hemin, otherwise known as synthetic heme. The ability for hemin to polymerize into β-hematin provides the assay the characteristic capacity to be used as a means to study the inhibition of hemozoin formation (β-hematin). This study seeks to compare the β- hematin inhibitory potential of the methanol stembarks of Annickia affinis and Annickia chlorantha. Annickia affinis and Annickia chlorantha stembark extracts were observed to possess notable capability in inhibiting β-hematin formation with A. chlorantha performing better at inhibiting β-hematin formation than A. affinis

Asthma is an inflammatory disease of the lungs that causes oxidative stress (Almohawes and Alruhaimi, 2019). Asthma is characterized by airway inflammation, oxidative stress and increased Malondialdehyde level. It doesn’t have a cure cannot be treated but it was discovered that a plamt known as adansonia digitata commonly referred to as African Baobab. The leaves
of this tree serve as a primary source of food and traditional medicine for numerous African populations, and they are consumed either fresh or in a dried form (Besco et al., 2007). The plant have effects on asthma due to its renowned for its pharmacological properties including anti inflammatory and anti-oxidant properties. This study aims at providing valuable insights into the therapeutic potential of adansonia digitata in managing asthma by its modulation of Malondialdehyde levels and contribute to supporting the use of natural products for management of asthma.

The study investigates the impact of the aqueous-methanol extract of Azanza garckeana on
histological parameters in Wistar albino rats. Azanza garckeana, commonly known as African
wild loquat, is recognized for its medicinal properties. The project aims to explore its potential
effects on the microscopic structure of tissues in rats, focusing on organs such as the liver, kidney, and heart. The research methodology involves the extraction of bioactive compounds
from Azanza garckeana using a mixture of water and methanol, followed by administration to
the experimental group of rats. Histological analyses are conducted to assess any alterations in
tissue architecture, cellular morphology, and pathological changes compared to the control group. Histopathological findings from this study revealed no alteration in the organs; liver, kidney, heart, colon and testis of male Wistar albino rats administered aqueous-methanol root extract of
Azanza garckeana. These findings indicate that the plant extract did not compromise the cellular
integrity nor inflict damage to these organs. The findings provide insights into the potential
therapeutic or adverse effects of Azanza garckeana extract on organ health, contributing to our
understanding of its pharmacological properties. This investigation holds significance in the field
of biochemistry by elucidating the biological mechanisms underlying the effects of natural
products on histological parameters, which could pave the way for further exploration of Azanza
garckeana as a potential source of novel pharmaceutical agents

Cyanide poisoning poses a significant threat to cardiovascular health, leading to the development of cardiovascular disease (CVD) risk factors such as dyslipidemia, oxidative stress, and endothelial dysfunction. Ocimum gratissimum (OG), commonly known as scent leaf, is a medicinal plant with potential cardioprotective properties. This study aimed to investigate the effect of the ethanol extract of OG on CVD risk factors in cyanide-induced rabbits. Fifteen rabbits were randomly divided into five groups: group one(drug), group two(ethanol extract), group three(ethanol extract), group four(cyanide), group five(control). Cyanide-induced rabbits were orally administered OG extract and drug(Sylimarin) for 21 days. Blood samples and organs(heart) were collected for biochemical analysis of CVD risk factors, including total protein profile, cholesterol levels, arterogenic coefficient, cardiac risk ratio, vitamin, and nitric oxides concentration. Certain experimental groups displayed promising changes, such as elevated HDL- C levels, improved endothelial function, and enhanced cardiac muscle function, others exhibited
adverse alterations in lipid profile and endothelial function. These findings underscore the complex nature of herbal remedies and emphasize the importance of empirical validation to ensure their safety and efficacy in treating cardiovascular diseases.