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Abstract
Antimicrobial Resistance (AMR) occurs when bacteria, viruses, fungi, and parasites no longer respond to antimicrobial agents. As a result of drug resistance, antibiotics (usually used for bacteria) and other antimicrobial agents become ineffective, and infections become difficult or impossible to treat, increasing the risk of disease spread, severe illness, disability, and death. This study comprehensively investigated the antimicrobial susceptibility patterns of Staphylococcusaureus isolated from paediatric patients. The study adopted a cross-sectional epidemiological design. The participants of the study include paediatric patients aged 2–17 years within UBTH with clinically diagnosed bacterial infections or paediatric patients who were suspected to eventually receive antibiotic treatments. A total of 53 samples were collected from this population, using rectal and nasal swabs, these samples were cultured on MacConkey agar and mannitol salt agar respectively. Isolates were characterized using conventional cultural
techniques. The findings of the study showed that the mean age of the population is between30.5-117.5 months, With male gender being predominant in the study. Atotal of 53Staphylococcus isolates were identified, comprising 36(67.9%) S. aureus and 17(32.1%)Coagulase negative Staphylococcus aureus (CoNS). The antimicrobial susceptibility profile of Staphylococcus aureus isolates, indicated a high level of susceptibility to majority of the antibiotics; including amikacin, amoxicillin-clavulanic acid, tigecycline, meropenem, levofloxacin, erythromycin, cefuroxime, and tetracycline. Resistance was most pronounced against cefoxitin, cefazidime, ciprofloxacin, erythromycin, and sulfamethoxazole-trimethoprim, where significant proportions of isolates were resistant (ranging from approximately45%to80%). Based on the findings of this study, it can be infer that there is mild-high range of AMR among paediatric patient in Benin City. The study thus, supports the need for necessary action, including rational drug use, continuous surveillance, and deployment of adequate preventive and curative policies and actions
techniques. The findings of the study showed that the mean age of the population is between30.5-117.5 months, With male gender being predominant in the study. Atotal of 53Staphylococcus isolates were identified, comprising 36(67.9%) S. aureus and 17(32.1%)Coagulase negative Staphylococcus aureus (CoNS). The antimicrobial susceptibility profile of Staphylococcus aureus isolates, indicated a high level of susceptibility to majority of the antibiotics; including amikacin, amoxicillin-clavulanic acid, tigecycline, meropenem, levofloxacin, erythromycin, cefuroxime, and tetracycline. Resistance was most pronounced against cefoxitin, cefazidime, ciprofloxacin, erythromycin, and sulfamethoxazole-trimethoprim, where significant proportions of isolates were resistant (ranging from approximately45%to80%). Based on the findings of this study, it can be infer that there is mild-high range of AMR among paediatric patient in Benin City. The study thus, supports the need for necessary action, including rational drug use, continuous surveillance, and deployment of adequate preventive and curative policies and actions
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