AJUFOH CHUKWUDUMEBI JESSY

The aim of this study was to evaluate the effects of methanol extract of Spondias mombin also known as yellow mombin (YM) on urea and creatinine levels in high fat fed diets. A total of 45 albino Wistar rats were randomized into five groups each of nine animals as follows:Group 1 (Normal Control): Rats fed with standard diet and with no high-fat diet or extract treatment,Group 2 (HFD Control): Rats fed with high-fat diet without any treatment,Group 3 (HFD + Low Dose Spondias mombin Extract): Rats fed with high-fat diet and treated with 200 mg/kg body weight of Spondias mombin extract,Group 4 (HFD + High Dose Spondias mombin Extract): Rats fed with high-fat diet and treated with 400 mg/kg body weight of Spondias mombin extract,Group 5 (HFD + Spondias mombin ): Rats fed with high-fat diet and treated with The methanol extract was administered via oral gavage once daily for four weeks. The choice of oral administration reflects the potential human application of the plant extract as a dietary supplement or therapeutic agent.YM has a high antioxidant activity and significant amounts of phenolic compounds, carotenoids, vitamin C, dietary fibre, and minerals.The results show that Group 1 had a mean creatinine level of (0.65 ± 0.07 mg/dL), while Group 2 had a mean creatinine level of (0.83 ± 0.04 mg/dL). Groups 3, 4, and 5 had mean creatinine levels of 0.75 ± 0.07 mg/dL, 0.78 ± 0.11 mg/dL, and 0.75 ± 0.07 mg/dL, respectively and Group 2 had significantly higher urea levels compared to Groups 1, 3, and 5.This suggests that the high-fat diet without Spondias mombin extract supplementation led to increased creatinine levels, indicating impaired kidney function. On the other hand, Groups 1, 3, and 5, which received Spondias mombin extract supplementation, had lower creatinine levels, indicating improved kidney function.