WINIFRED OBEHI INEGBEDION

Quinoline or benzopyridine, a nitrogen containing compound has been known to possess antimalarial, anti-bacteria, and anti-fungal properties. In this study, a derivative of quinoline-N-oxide-4-thiol was obtained by a five step reaction. The compounds synthesized in the stepwise reactions were: quinoline-N-oxide, 4- nitroquinoline-N-oxide, 4-chloroquinoline-N-oxide and quinoline-N-oxide-4-thiol. Furthermore, the latter was coupled with benzoyl chloride under basic condition to obtain quinoline-N-oxide-4-benzoylsulphide. The physical properties of the compound obtained are percentage yield 1.86%, melting point 96-98 oC, and retention factor value 0.83.