SERUM AMYLASE

Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia, or elevated blood glucose levels, resulting from defects in insulin secretion, insulin action, or both. This study focused on the severe metabolic imbalance caused by Streptozotocin (STZ) induction in male Wistar rats . Diabetes mellitus was induced in male Wistar rats by a combination of a 2-week high-carbohydrates diet, followed by double doses (60 and 40 mg/kg respectively) of intraperitoneal injection of STZ. Diabetic rats were then treated for two weeks with either distilled water (control), Glibenclamide (5 mg/kg, positive control), or picralima nitida extract at two doses (200 mg/kg and 500 mg/kg). The findings revealed that all groups treated with Picralima nitida showed a decrease in α-amylase levels compared to the diabetic group that received no treatment. However, this reduction was not sufficient to bring the enzyme activity back to the levels observed in non-diabetic (control) rats. Among the doses tested, the low dose produced the most stable regulatory effect, showing results that were comparable, though slightly less effective, than glibenclamide